NMR STUDIES OF SECA ATPASE

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 所有的细胞都必须将蛋白质运输穿过细胞膜。这一基本过程负责膜和细胞壁的生物发生、运动性和营养物的清除和吸收，并且还涉及发病机制和共生。移位酶是一种令人印象深刻的动态纳米机器，是催化跨膜交叉的中心组分。这种复杂的多阶段反应涉及分子间和分子内相互作用的级联，其选择、分选和靶向多肽至膜，并使用能量以高保真度和效率促进这些多肽穿过磷脂双层的运动或其侧向逃逸和整合。SecA是Sec易位机制的大的204 kDa马达蛋白。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. All cells must traffic proteins across their membranes. This essential process is responsible for the biogenesis of membranes and cell walls, motility and nutrient scavenging and uptake, and is also involved in pathogenesis and symbiosis. The translocase is an impressively dynamic nanomachine that is the central component which catalyses transmembrane crossing. This complex, multi-stage reaction involves a cascade of inter- and intramolecular interactions that select, sort and target polypeptides to the membrane, and use energy to promote the movement of these polypeptides across--or their lateral escape and integration into--the phospholipid bilayer, with high fidelity and efficiency. SecA is a large 204 kDa motor protein of the Sec translocation machinery.