ANIMAL MODELS FOR AIDS VACCINE DEVELOPMENT

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 我的研究小组致力于利用人类和动物病毒系统，如人类免疫缺陷病毒1型(HIV-1)、猴免疫缺陷病毒(SIV)和马传染性贫血病毒(EIAV)，了解慢病毒持续存在和致病的分子机制。我们对慢病毒持久性研究的一个主要焦点是病毒种群在疾病不同阶段的演化特征，持续感染期间病毒准种对不同组织的划分，以及病毒变异对病毒免疫学特性的影响。这些HIV-1进化研究是在NIH资助的多中心艾滋病队列研究中的HIV-1感染受试者中进行的。在这些HIV-1研究的同时，利用感染SIV的猴子或感染EIAV的马的实验感染来检查基因组和抗原变异在病毒持久性和发病机制中的性质和作用。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The efforts of my research group focus on understanding the molecular mechanisms of lentiviral persistence and pathogenesis using human and animal virus systems, e.g. human immunodeficiency virus type 1 (HIV-1), simian immunodeficiency virus (SIV), and equine infectious anemia virus (EIAV). A major focus of our studies of lentiviral persistence is the characterization of the evolution of viral populations during various stages of disease, the compartmentalization of viral quasispecies to different tissues during persistent infection, and the effects of viral variation on viral immunological properties. These HIV-1 evolution studies are performed in HIV-1 infected subjects that are part of the NIH-funded Multicenter AIDS Cohort Study. In parallel to these HIV-1 studies, experimental infections of monkeys with SIV or horses with EIAV are utilized to examine the nature and role of genomic and antigenic variation in viral persistence and pathogenesis.