FOLDING MECHANISM OF ? F508 CFTR IN A NONOSIZED CONFINEMENT

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 研究了F508CFTR在不同约束条件下的折叠机理。包括突变/重量蛋白的纳米受限系统被设计成模拟细胞环境。限制溶剂是我们模型中考虑的另一个重要因素。这就需要使用显式溶剂模型来模拟大系统。这些模拟将有助于我们更好地理解CFTR在生物系统中的错误折叠。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The folding mechanism of ?F508 CFTR is investigated under different confinement conditions. Nanosized confined system that include the mutant/wt protein are designed to mimic the cellular environment. Confining the solvent is another importatn factor that is accounted for in our models. This requires simulating large systems using explicit solvent model. These simulations will help improve our understanding of the misfolding of CFTR in living systems.