STUDIES OF WTR DYNAMICS BY T1RHO AND T2RHO MRI IN ACUTE CEREBRAL ISCHEMIA RAT

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目及 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者的研究机构。 旋转帧弛豫MRI对比度，T1 rho和T2 rho，被认为是超急性卒中组织变化的敏感指标。在这项工作中，我们正在调查的变化，T1 rho和T2 rho MRI的梗死脑，最近表明，在超急性中风的变化反映了自由水池的大小增加，减少翻滚的水分子与大分子，并增加自由和大分子网站之间的水交换。这些发现与血管源性水肿、破坏性过程和组织酸化一致。这项研究为脑缺血的物理化学过程提供了新的见解

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Rotating frame relaxation MRI contrast, T1rho and T2rho, are thought to provide sensitive indicators of tissue changes in hyperacute stroke. In this work, we are investigating the changes in T1rho and T2rho MRI of infarcting brain, and have recently shown that the changes in hyperacute stroke reflect an increase in the free water pool size, decreased tumbling of the water molecules associated with macromolecules, and increased water exchange between free and macromolecular sites. These findings are consistent with vasogenic edema, destructive processes and tissue acidification. This research is providing new insights into the physico-chemical processes occurring in brain ischemia