PRECISION PHANTOMS DESIGN AND FABRICATION FOR ESR MICROSCOPY

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 沿着样品制备方法的发展，有必要对具有良好定义和表征的体模的ESR显微镜仪器进行初步评价。表征不是一个简单的过程，因为测试样品必须包含位于三维结构中各个位置的自由基，其精度优于微米。因此，这些测试样品的制造本身就是一项重要的任务，必须在我们的仪器研发工作中完成。在其他类型的测试样品中，我们将考虑1）放置在良好表征的3D结构上的特定位置处的微观自由基颗粒和2）填充玻璃结构中的特定孔的三苯甲基掺杂的液体和LiNc-BuO悬浮液。这两种类型的定义明确的微样品将在康奈尔纳米生物技术中心的帮助下制造（如我们以前的9 GHz c.w.工作）和先进的光刻和亚微米级处理能力的康奈尔纳米科学与技术设施（CNF）。 博士Shin最近加入了我们的ACERT工作人员，他已经完成了CNF资格认证计划，并将于2008年夏天启动该子项目。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. It is necessary, along with development of sample preparation methods, to perform initial evaluation of the ESR microscope instruments with well defined and characterized phantoms. Characterization is not a trivial procedure because the test samples must contain radicals positioned in various locations in a three dimensional structure with accuracy better than a micron. Therefore, the fabrication of these test samples represents a significant task on its own that must be accomplished in the context of our instrumentation r & d effort. Among other types of test samples, we will consider 1) microscopic radical grains placed at specific locations on a well-characterized 3D structure and 2) trityl-doped liquid and LiNc-BuO suspensions that fill specific holes in a glass structure. These two types of well defined micro-samples will be fabricated with the aid of Cornell Nano-Biotechnology Center (as done in our previous 9GHz c.w. work) and the advanced photolithography and sub-micron scale processing capabilities of the Cornell NanoScale Science & Technology Facility (CNF). Dr. Shin, who has recently joined our ACERT staff, has completed the CNF qualification program and will initiate this subproject in summer 2008.