AUDITORY & VISUAL INTEGRATION IN SCHIZOPHRENIA EXAMINED USING MEG, EEG & FMRI

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 项目2旨在使用生态上有效的实验设计(即足球场景)来研究精神分裂症患者(SP)与健康正常志愿者(HNV)的大脑如何跨听觉和视觉模式整合信息。在先前的综述中提出的一个关注集中在从单一感觉加工的缺陷中找出多感觉整合的缺陷。我们已经在我们的fMRI和MEG/EEG范例中解决了这一问题，方法是检查单感觉听觉和视觉反应与多感觉听觉/视觉刺激之间的差异，并独立地表征单感觉反应。虽然我们确实期望看到SPS和HNV之间的单感觉反应的差异，但我们预测多感觉整合效应的影响更大，表现为延迟或幅度降低。在所有阶段确定这些变化的特征，对于充分理解这一范式确定的缺陷至关重要。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Project 2 was designed to use an ecologically valid experimental design (i.e., a soccer scenario) to study how the brain integrates information across the auditory and visual modalities in patients with schizophrenia (SP) compared to healthy normal volunteers (HNV). A concern raised in previous review centered on sorting out deficits in multisensory integration from deficits in unisensory processing. We have addressed this concern in our fMRI and MEG/EEG paradigms by examining differences between unisensory auditory and visual responses compared to multisensory auditory/visual stimuli and by characterizing the unisensory responses independently. While we do expect to see differences in the unisensory responses between SPs and HNVs, we predict greater effects for the multisensory integration effects, expressed as delays or reductions in amplitude. Characterizing these changes at all stages is critical to fully understand the deficits identified by this paradigm.