MOLECULAR MECHANISMS OF ESTROGEN-REGULATED BONE RESORPTION

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 这个项目的主要目的是加深我们对伴随雌激素缺乏而导致的骨吸收增加的机制的理解。比较了6个月龄对照组、去卵巢(OVX)组、激素替代疗法(HRT)组、钙通道拮抗剂(地尔硫卓、硝苯地平、维拉帕米)组和联合用药组的骨吸收参数。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The primary objective of this project is to enhance our understanding of the mechanisms of increased bone resorption, which accompanies estrogen deficiency. Bone resorption parameters have been compared between control females six months of age, ovariectomized females (OVX), females receiving hormone replacement therapy (HRT), and females receiving a calcium channel antagonists (Diltiazem, Nifedipine, Verapamil), or females receiving a combination of the two agents.