Pathogenesis and Treatment of HIV Infection

艾滋病毒感染者的免疫系统被发现具有一种独特的激活形式，以不同的方式影响免疫系统的不同部分。辅助(CD4+)T细胞的激活是由这些细胞的丧失以及HIV水平驱动的，而细胞毒性(CD8)T细胞的激活仅由HIV水平驱动。 对感染了HIV样病毒SIV的恒河猴的辅助(CD4)T细胞库的成像表明， 西非国家马里的许多流行的艾滋病毒类型被发现由重组病毒组成。 血液中炎症标记物白介素6和凝血标记物D-二聚体的水平被发现是艾滋病毒感染患者死亡率的强烈预测因素。

The immune systems of patients with HIV infection were found to be characterized by a unique form of activation that effects different parts of the immune system in different ways. The activation fo helper (CD4+) T cells was driven by the loss of these cells as well as the levels of HIV while the activation of cytotoxic (CD8) T cells was only driven by the levels of HIV. Imaging of the helper (CD4) T cell pool of rhesus monkeys infected with the HIV-like virus SIV demonstrated that Many of the circulating types of HIV in the West African country of Mali were found to be comprised of recombinant viruses. Blood levels fothe the inflammatory marker interleukin-6 and the coagulation marker D-dimer were found to be strong predictors of mortality in patients with HIV infection.