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Role of Inflammation in the Development and Progression of Pancreatic Cancer

Role of Inflammation in the Development and Progression of Pancreatic Cancer
炎症在胰腺癌发生和进展中的作用
批准号：
7966177
负责人：
Syed Hussain
金额：
$21.76万
依托单位：
DIVISION OF BASIC SCIENCES - NCI
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/7966177
关键词：
ApoptosisBreastCancer PatientCell Cycle ArrestChronicColonContractsDNA RepairDataDevelopmentDiseaseFamilyFreezingGene ExpressionGenesGenetic PolymorphismGoalsGrowthHeadHumanIL8 geneImmuneImmune responseIn VitroInflammationInflammatoryInflammatory ResponseInheritedInterleukin-6LungMalignant NeoplasmsMalignant neoplasm of liverMalignant neoplasm of pancreasMarylandMediatingMediator of activation proteinMicroRNAsMigration Inhibitory FactorModelingMolecularMolecular ProfilingNOS2A geneNeoplastic Cell TransformationNitric OxidePancreasPancreatic Ductal AdenocarcinomaPancreatitisParaffinPathway interactionsPatientsPhosphorylationPhosphotransferasesPlayPolymerase Chain ReactionPrevention therapyProstateProteinsRNARegulationReportingResourcesRiskRoleSamplingSeveritiesStaining methodStainsTechniquesTestingTimeTumor BiologyTumor Necrosis Factor-alphaTumorigenicityUbiquitinationUniversitiescytokinehuman TNF proteinoutcome forecastpancreatic neoplasmphenylpyruvate tautomerasetranscription factortumor

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中文摘要
翻译
我们已经启动了这个项目，并从25对快速冷冻的胰腺导管腺癌（PDAC）样本和来自同一患者的周围非肿瘤胰腺以及通过nci -马里兰大学资源合同收集的来自非癌症捐赠者的3对正常胰腺中分离出RNA。利用实时聚合酶链反应技术对这些RNA样本进行分析，以确定一组25个炎症基因的表达。对同一组样品的石蜡切片进行免疫组化染色，检测NOS2、phospho-FoxO、MIF和phospho-Akt的表达。
英文摘要
We have started this project and isolated RNA from 25 pairs of snap-frozen pancreatic ductal adenocarcinoma (PDAC) samples and the surrounding non-tumorous pancreas from the same patients and 3 normal pancreas from non-cancer donors that have been collected through the NCI-University of Maryland Resource Contract. These RNA samples are being analyzed to determine the expression of a set of 25 inflammatory genes with real-time polymerase chain reaction technique. Paraffin sections of the same sample set are being examined for the expression of NOS2, phospho-FoxO, MIF and phospho-Akt by immunohistochemical staining.
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Role of Immune and Inflammation Mediators in Progression of Pancreatic Cancer
Forkhead-box (FOX) Transcription Factors in the Progression of Pancreatic Cancer
Integrative Molecular Profiling of Human Pancreatic Cancer
Animal model of Pancreatic Cancer
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