Mechanism and effect of exenatide on weight loss: Randomized controlled trial

志愿者将被筛选并进入我们的住院临床研究单元。他们将在整个房间的间接量热计中接受葡萄糖耐量、食物摄入量和能量消耗的基线测量。在随机分为活性药物或安慰剂后，这些测量将重复进行。在基线入院后，志愿者将首先作为门诊患者每周接受一次跟踪(为期一个月)，然后每月进行一次跟踪，持续5个月。然后，志愿者将重新入院，重复测量食物摄入量。然后，所有志愿者都可以选择在接下来的6个月里继续使用艾塞那肽的开放标签，在此期间，他们将再次每月接受跟踪。 这项研究目前正在招募志愿者。 截至目前的出版物：无

Volunteers will be screened and admitted to our inpatient clinical research unit. They will undergo baseline measurements of glucose tolerance, food intake and energy expenditure in a whole room indirect calorimeter. After randomization to active drug or placebo, these measurements will be repeated. After the baseline admission, volunteers will be followed as outpatients initially on a weekly basis (for one month), followed by a monthly basis for another 5 months. Volunteers will then be readmitted for repeat measurements of food intake. All volunteers will then have the option of open label use of exenatide for another 6 months during which time they will again be followed monthly. The study is currently recruiting volunteers. Publications to date: None