Nutrient Absorption in Lean Versus Obese Individuals

这项研究对肥胖和瘦弱的人进行了两种标准饮食（卡路里含量不同）和粪便和尿液能量损失的比较，以比较瘦弱和肥胖的人的这些值。该研究还调查了粪便中特定的常量营养素含量，以检查瘦和肥胖个体之间这些参数的差异。这些测量的可重复性也正在一小部分个体中进行测试。与圣路易斯华盛顿大学杰弗里·戈登博士的实验室合作，粪便样本将被送去测定粪便细菌菌群的种类，以检查粪便能量损失与肠道菌群数量之间的关系。

This study examines obese and lean individuals on two standard diets (which differ by calorie content) and the stool and urine energy losses to compare these values in lean versus obese individuals. The study is also investigating the specific macronutrient content of stool to examine differences in these parameters between lean and obese individuals. The repeatability of these measurements is also being tested in a subset of individuals. In collaboration with Dr. Jeffrey Gordons lab at Washington University in St. Louis, samples of stool will be sent for determination of the fecal bacterial flora phylotypes to examine the association between stool energy loss and enteric flora populations. Preliminary results from an initial 14 lean and 9 obese individuals failed to show any difference in stool or urine energy loss. The range of calories stool was large, varying from 2 to 9 % in both groups. Stool calorie loss on each diet was associated in each individual. On the higher calorie diet, obese individuals had greater stool calorie loss (so absorbed less food ) than lean. Preliminary results show acute changes in gut bacteria with nutrient load.