Indiana PROSPECT

描述(由申请人提供)：印第安纳州的前景建立在全国最大、最复杂的健康信息交换基础上，该交换已包含超过25亿份结构化观察和3800万份文本文档，涉及1000多万名患者。这一资源已经被用于各种临床结果和临床有效性研究。根据我们对基础设施方面的差距和通过进行特定CER研究作为前景一部分获得的经验的分析，我们将增强基础设施以捕获更丰富的临床数据，特别是增强我们纳入患者结果的能力、改进设备利用率数据的捕获、整合基因组和其他高通量结果的能力、识别患者以进行招募和登记的先进技术。为了证明这种环境的可用性，并为其进一步发展提供信息，我们提议进行一个新的CER项目，评估阿尔茨海默病的治疗。CER研究将评估药物治疗阿尔茨海默病的行为症状。阿尔茨海默病已被确定为CER的第一个四分位数的优先事项。因为我们的方法是以人口为基础的，我们将纳入一个重要的少数族裔人口。该应用程序代表了Regenstrief Institute，Inc.(医疗信息技术的世界领先者)的医疗信息学项目与印第安纳大学的两个研究项目之间的合作：老龄化研究中心和临床药理学部门。这些方案在与未得到充分服务的人群相关的研究方面有既定的记录。因此，这项申请结合了相当大的研究人员、环境和研究优势，以继续建立一个新的CER基础设施，以支持国家的证据CER优先事项。我们将在我们既定的治理方法的基础上，测试和改进共享访问这些研究数据库的方法和基于创造价值的可持续性财务模型。 公共卫生相关性：项目描述这项提案旨在加强印第安纳州中部现有的信息技术基础设施，以提高国家进行比较有效性研究(CER)的能力，并将这些新能力应用于评估阿尔茨海默病治疗的新CER项目。

DESCRIPTION (provided by applicant): The Indiana PROSPECT builds on the nation's largest, most sophisticated health information exchange that already contains over 2.5 billion structured observations and 38 million text documents for over 10 million patients. This resource is already used for a variety of clinical outcomes and clinical effectiveness research. Based on our analysis of gaps in the infrastructure and experience gained by conducting a specific CER study as part of the PROSPECT, we will enhance this infrastructure to capture richer clinical data and particularly enhance our ability to incorporate patient outcomes, improved capture of device utilization data, capabilities to incorporate genomic and other high throughput results, advanced technologies to identify patient for recruitment and enrollment technologies. In order to demonstrate the usability of this environment and to inform its further development, we propose to conduct a novel CER project evaluating treatment for Alzheimer's. The CER study will evaluate of medication treatment for behavioral symptoms of Alzheimer's disease. Alzheimer's disease has been identified as a first quartile CER priority. Because our approach is population based, we will incorporate a significant minority population. This application represents collaboration between the Medical Informatics Program at the Regenstrief Institute, Inc (a world leader in health information technology) and two Indiana University research programs: the Center for Aging Research and the Division of Clinical Pharmacology. These programs have an established track record in research relevant to under-served populations. Thus, this application combines considerable investigator, environment, and research strengths to continue to build a novel CER infrastructure in support of the nation's evidentiary CER priorities. We will build on our established governance approach to test and improve approaches for sharing access to these research databases and financial models for sustainability based on value created. PUBLIC HEALTH RELEVANCE: Project Narrative This proposal seeks to enhance the existing information technology infrastructure in Central Indiana to improve the nation's capacity to conduct comparative effectiveness research (CER) and apply these new capacities to a novel CER project evaluating treatment for Alzheimer's disease.