To demonstrate the feasibility of a home tonometer to monitor IOP without contact

描述（由申请人提供）：本研究旨在研究一种基于双色频闪技术（TCST）的家用眼压计的可行性，该眼压计由Achevi technology旗下的CeeMaxTM Ophthalmic公司开发。我们是眼科诊断仪器的制造商，拥有固态照明和数字图像系统的核心专业知识。我们的家用非接触式眼压计不需要特殊技能使用。一旦批准可行，它将允许数千名进行性青光眼损伤患者在两次就诊之间跟踪他们的眼压（IOP），并向他们的医生提供他们个人眼压水平和波动的完整图像。该装置将扩大我们对青光眼进展的认识，改善青光眼的管理，促进青光眼的早期诊断，加强青光眼的药物或手术治疗。该系统将提供相关的角膜解剖参数，本研究的目的之一是创建一种算法，使IOP的推导独立于角膜的生物力学特性。为了验证我们的设计，我们将TCST的结果与Goldmann眼压计的结果进行比较，该眼压计具有包括各种“角膜”结构的人工眼睛模型。将使用校准的压力计作为参考，比较两种测量的准确性和可重复性。如果TCST测量的精度达到11mmhg，其可重复性与Goldmann血压计测量的可重复性相当，我们将得出结论，我们的创新是可行的。我们正在申请专利的概念需要一个类似于现代手机的多色固态闪光灯的数字图像系统。因此，该装置可以经济地制造。由于数字图像文件的大小相对较小，因此来自该设备的信息非常易于跟踪和管理。IOP信息可以在本地获得，也可以通过互联网远程记录和分析。除了对青光眼治疗的贡献外，本研究将为三维前房地形增加另一个维度。它将角膜的模量和/或其他相关力学性能添加到角膜的解剖参数中。因此，这项研究可以演变成一种新的动态地形学，将扩大我们对角膜的了解，并进一步完善屈光手术。由于其与角膜形状的独立性，该装置也将解决圆锥角膜患者未满足的护理，圆锥角膜是美国最常见的角膜营养不良。

DESCRIPTION (provided by applicant): This research is to study the feasibility of an in-home tonometer based on the two color strobe technology (TCST) developed by CeeMaxTM Ophthalmic, a division of Achevi Technology. We are the manufacturer of ophthalmic diagnostic instruments with core expertise of solid state lighting and digital image systems. Our in-home non-contact tonometer does not require special skills to use. Once it approves feasible, it will allow thousands of patients with progressive glaucomatous damage to keep track of their intraocular pressure (IOP) between office visits and to provide their physicians with a complete picture of their individual IOP level and fluctuations. This device will expand our understanding of the glaucoma progression, improve glaucoma management, promote early diagnosis and enhance glaucoma medication or surgical treatment. The system will provide the relevant cornea anatomical parameters and one of the aims of this research is to create an algorithm enable the derivation of an IOP independent of the biomechanical properties of cornea. To validate our design we will compare the results of TCST with the results of a Goldmann applanation tonometer with an artificial eye model that includes various "cornea" configurations. Accuracy and repeatability of both measurements will be compared using a calibrated manometer as reference. We will conclude our innovation is feasible if TCST measurement demonstrates an accuracy of 11mm Hg and its repeatability is comparable with the repeatability of Goldmann tonometer measurements. Our patent pending concept requires a digital image system similar to a modern day cell phone with multi-color solid state strobes. Thus the device can be manufactured economically. The information from this device is very traceable and manageable because the size of the digital image file is relatively small. The IOP information can be derived locally or can be recorded and analyzed remotely via internet. In addition to the contribution to glaucoma management, this research will add another dimension to the 3-D anterior chamber topography. It will add the modulus and/or other relevant mechanical properties of cornea to the anatomical parameters of the cornea. Thus, this research could evolve into a new dynamic topographer that will expand our understanding of the cornea and further refine the refractive surgeries. Due to its independence of the cornea shape, this device will also address the unmet care for patients with keratoconus, the most common corneal dystrophy in the United States. . PUBLIC HEALTH RELEVANCE: This research will generate an important tool for the management of glaucoma, especially for early detection of glaucoma and for customized medication and/or surgical procedures, through two-color-strobe- technology (TCST) to achieve easy-to-use home monitoring of intraocular pressures (IOP) without contacting the cornea. This will allow quick detection and accurate IOP-based glaucoma events for use of event-adjusted therapeutics that will avoid the current adverse time delays that are associated with sporadic clinical visits in care of glaucoma patients.