A Systems Biology Platform for the Assessment of Substance Abuse

描述（由申请人提供）：该项目的目标是开发一个数据库和数据分析平台，专门用于研究药物滥用的原因和生物学后果。该产品将包括：i)基因、其蛋白质产物与药物滥用倾向、依赖的发展和与慢性药物滥用相关的病理之间关联的综合疾病本体和数据库；Ii)与药物滥用及其对多器官系统的影响有关的公开可用的系统生物学数据集（基因表达、蛋白质组学、代谢组学）的集合；Iii)一套与药物依赖相关的预先构建的地图和网络，以及软件工具，这些工具将能够独立或组合地分析现有和新生成的系统生物学数据集，以确定疾病发展的代谢和信号网络、途径和机制，以及治疗干预的潜在策略和目标；Iv)用于分析新化合物的计算工具，以预测其滥用和依赖的可能性。该产品将在市场上独一无二，并引起学术研究人员、基金会和制药公司的极大兴趣，这些研究人员正在研究酒精中毒和酒精相关疾病的原因和治疗，并将由GeneGo作为metaddiscovery产品套件的一部分进行营销和销售。

DESCRIPTION (provided by applicant): The goal of this project is to develop a database and data analysis platform specifically designed for the study of the causes and biological consequences of drug abuse. The product will comprise: i) a comprehensive disease ontology and database of associations between genes, their protein products and predisposition to drug abuse, development of dependency and pathologies associated with chronic drug abuse; ii) a collection of publicly-available systems biology datasets (gene-expression, proteomics, metabolomics) relating to drug abuse and it's affects on multiple organ systems; iii) a set of prebuilt maps and networks relating to drug dependency, and software tools that will enable the analysis of extant and newly-generated systems biology datasets, independently and in combination, to identify metabolic and signaling networks, pathways, and mechanisms of disease development, and potential strategies and targets for therapeutic interventions; iv) computational tools for the analysis of novel compounds to predict their potential for abuse and dependency. The product will be unique in the marketplace and of great interest to academic researchers, foundations and pharmaceutical companies performing research into the causes and treatment of alcoholism and alcohol- related disease and will be marketed and sold by GeneGo as part of the MetaDiscovery suite of products. PUBLIC HEALTH RELEVANCE: The aim of this grant is to develop a software database and analysis platform to enable a systems-level approach to understanding, preventing and treating drug abuse. The platform will provide a comprehensive knowledge-base, data analysis tools and predictive models to support research into the causes and treatment of drug abuse.