Request for VivaCT 75 High Speed in vivo MicroCT Scanner

描述（由申请人提供）：本提案的目的是获得资金，以购买一台Sampoo VivaCT 75高速体内微型计算机断层扫描（CT）仪器，用于在使用小动物（小鼠和大鼠）模型的纵向研究中对小梁和皮质骨特性进行三维成像和定量分析。马萨诸塞州医学院（UMMS）校园或马萨诸塞州中部伍斯特地区的任何学院和大学都没有类似的仪器。该体内CT扫描仪将由8名用户共享，用于评估遗传小鼠或大鼠模型中的骨骼异常，设计和表征用于加速骨修复的新生物材料植入物，并解决骨关节炎，类风湿性关节炎和转移性骨疾病的新治疗方法。这些正在进行的研究可以显着受益于仪器的能力，进行纵向表征的骨组织和定量的多个参数，反映骨形成和吸收活的小动物。UMMS在癌症、衰老、糖尿病和骨科护理领域的转化研究的长期增长，其中在小动物模型中与这些疾病相关的骨骼并发症的测试可以通过非侵入性体内CT成像能力来刺激。 公共卫生相关性：所要求的Sonio VivaCT 75高速体内微型计算机断层扫描（<$CT）仪器将提供生成定量数据的手段，这些数据对于评估骨表型、骨病理和抑制骨吸收和刺激骨形成的新型治疗策略是必要的。该仪器将有助于治疗许多主要健康问题领域的骨骼疾病：1）由于创伤、衰老、代谢性疾病和肿瘤切除而导致的难以愈合的骨骼缺陷; 2）使人衰弱的骨转移性疾病;以及3）影响全球数百万人的骨关节炎和类风湿性关节炎中的骨丢失。

DESCRIPTION (provided by applicant): The goal of this proposal is to acquire funds to purchase a Scanco VivaCT 75 high speed in vivo micro- computed tomography (<CT) instrument for 3-dimensional imaging and quantitative analyses of trabecular and cortical bone properties in longitudinal studies using small animal (mouse and rat) models. There is no similar instrument available on the University of Massachusetts Medical School (UMMS) campus or in any of the colleges and universities in the Worcester, central Massachusetts area. This in vivo <CT scanner is to be shared among 8 users for the assessment of skeletal abnormalities in genetic mouse or rat models, design and characterization of new biomaterial implants for expedited bone repair, and addressing novel therapeutic approaches for osteoarthritis, rheumatoid arthritis, and metastatic bone diseases. These on-going studies can significantly benefit from the instrument's capability to carry out longitudinal characterization of bone tissue and quantitation of multiple parameters that reflect bone formation and resorption in live small animals. The long- term growth of translational research at UMMS in the areas of cancer, aging, diabetes, and orthopedic care where the testing of the skeletal complications associated with these diseases in small animal models can be stimulated with the non-invasive in vivo <CT imaging capability. PUBLIC HEALTH RELEVANCE: The requested Scanco VivaCT 75 high-speed in vivo micro-computed tomography (¿CT) instrument will provide the means to generate quantitative data that is necessary for evaluating bone phenotypes, bone pathologies and novel therapeutic strategies to inhibit bone resorption and stimulate bone formation. This instrument will contribute to the treatment of skeletal disorders in a number of major areas of health concern: 1) hard-to-heal skeletal defects due to trauma, aging, metabolic diseases and tumor resection; 2) the debilitating metastatic diseases of bone; and 3) bone loss in osteoarthritis and rheumatoid arthritis that affects millions of people worldwide.