AB SCIEX QTRAP 5500 System

描述（由申请人提供）：圣裘德儿童研究医院的主要使命是通过研究和治疗为患有癌症和其他灾难性疾病的儿童找到治愈方法。最近在圣裘德的进展提供了一个更好地了解儿童癌症的分子，遗传和化学基础。这些发现为多种癌症的新靶点和治疗方式提供了新的见解。圣裘德的一项广泛的治疗药物发现计划已经确定了在儿童癌症的新临床前模型中进行评估的先导化合物。该申请的长期目标是支持新型小分子的临床前开发及其转化为儿童癌症的创新策略，包括急性淋巴细胞白血病，室管膜瘤，髓母细胞瘤，神经胶质瘤，视网膜母细胞瘤和其他实体瘤。使用拟议的最先进的LC/MS/MS系统，具体目标是开发，验证和实施抗癌药物，其代谢物或生物样品中其他相关药理学指标的灵敏度和特异性分析方法，以促进St. Jude临床前模型的高质量药代动力学/药效学转化研究。拟议的设备将有利于五个竞争性资助的同行评审的研究者和他们的项目，通过更大的检测选择性，特异性，效率和一致性，在应用最先进的设备和方法，临床前药代动力学项目。 公共卫生相关性：最近在圣裘德的进展提供了一个更好地了解儿童癌症的分子，遗传和化学基础。该项目将提供基于质谱的最先进的分析方法，以支持新型小分子的临床前开发及其转化为儿童癌症的创新疗法。

DESCRIPTION (provided by applicant): The primary mission of St. Jude Children's Research Hospital is to find cures for children with cancer and other catastrophic diseases through research and treatment. Recent progress at St. Jude has provided a better understanding of the molecular, genetic and chemical bases of cancer in children. These findings have provided new insights into novel targets and treatment modalities for multiple cancers. An extensive therapeutic drug discovery program at St. Jude has identified lead compounds to evaluate in novel preclincial models of childhood cancer. The long-term objective of this application is to support the preclinical development of novel small molecules and their translation to innovative strategies for childhood cancers including acute lymphoblastic leukemia, ependymoma, medulloblastoma, glioma, retinoblastoma and other solid tumors. With the proposed state-of-the-art LC/MS/MS system, the specific aim is to develop, validate and implement sensitive and specific analytical methods for anticancer agents, their metabolites, or other relevant pharmacologic indices in biological samples to facilitate high-quality pharmacokinetic/ pharmacodynamic translational research in pre-clinical models at St. Jude. The proposed equipment will benefit five competitively funded peer-reviewed investigators and their projects through greater assay selectivity, specificity, efficiency, and consistency in application of state-of-the-art equipment and approaches to preclinical pharmacokinetic projects. PUBLIC HEALTH RELEVANCE: Recent progress at St. Jude has provided a better understanding of the molecular, genetic and chemical bases of cancer in children. This project will provide state-of-the-art analytical methods based on mass spectrometry to support the preclinical development of novel small molecules and their translation to innovative therapies for children with cancer.