Neurobiological predictors of spoken and written language learning

描述（由申请人提供）：越来越多的证据支持将阅读障碍（RD）描述为获得流利阅读技能的基于大脑的困难，通常与语音处理缺陷相关（里昂等人，2003年）。在认知水平上，这些缺陷被认为阻碍了那些构成支持有效阅读所必需的词汇表征基础的拼写（O）、语音（P）和语义（S）特征的充分结合（cf. Harm & Seidenberg，1999; Perfetti &哈特，2001）。在脑系统水平上，神经影像学研究一致表明，相对于典型发育（TD）读者，RD读者在包括O，P和S处理的分布式电路的左半球（LH）区域显示出结构和功能差异。然而，目前我们还不知道这些结构和功能异常的发现中，哪些与阅读领域的特定学习问题有因果关系，哪些没有。关键的下一步是在受控的实验条件下生成和测试O，P和S学习中个体差异的预测模型。为此，我们将采用综合神经生物学和行为的措施，在新的口语和书面文字学习任务，以确定结构和功能的大脑差异预测单词学习困难的一般，以及最强的大脑预测因素是否随着O，P或S编码的相对要求而变化。此外，尽管普遍认为RD的主要缺陷出现在解码和语音处理技能的水平上，但临床，行为和神经影像学研究结果表明，在RD中将新学到的信息整合到永久记忆中存在其他问题。为了探索这一假设，我们将采用整合的大脑/行为分析来检查新学习的O，P和S形式的在线学习和离线巩固。为了更精确地研究巩固缺陷背后的神经机制，我们还将使用有针对性的语言和非语言学习任务，系统地调节对程序性与陈述性记忆系统的需求。对于所有这些语言和非语言的学习和巩固措施，我们测试特定的大脑为基础的TD/RD差异模型。 公共卫生相关性：拟议的研究将使用多种神经影像学方法来测试学习巩固中个体差异的预测模型：1）新颖的口语和书面文字学习任务，其对与阅读相关的组成过程的要求不同，和2）语言和非语言任务，系统地检查与程序性和陈述性记忆相关的皮层和皮层下神经系统的贡献，作为基本的阅读障碍（RD）的学习和巩固缺陷。总体目标是发展因果模型的方式，其中任何一个，或一些组合，这些功能和结构因素可能会阻碍语言和阅读相关的技能获取RD。

DESCRIPTION (provided by applicant): A growing body of evidence supports a characterization of reading disability (RD) as a brain-based difficulty in acquiring fluent reading skills, usually associated with phonological processing deficits (Lyon et al., 2003). At a cognitive level, these deficits are thought to impede adequate binding of those orthographic (O), phonological (P), and semantic (S) features that form the basis of lexical representations necessary to support efficient reading (cf. Harm & Seidenberg, 1999; Perfetti & Hart, 2001). At the level of brain systems, neuroimaging studies have consistently shown that, relative to typically developing (TD) readers, RD readers show both structural and functional differences at those left hemisphere (LH) regions that comprise the distributed circuitry for O, P, and S processing. At present though, we do not know which of these findings of structural and functional anomalies are causally related to specific learning problems in the domain of reading and which are not. A crucial next step is to generate and test predictive models of individual differences in O, P and S learning under controlled experimental conditions. To that end, we will employ integrated neurobiological and behavioral measures during novel spoken and written word learning tasks to determine which structural and functional brain differences predict word learning difficulties in general, and whether the strongest brain predictors vary as the relative demands on O, P or S coding are manipulated. Also, despite the general consensus that the primary deficit in RD arises at the level of decoding and phonological processing skills, there are clinical, behavioral, and neuroimaging findings which suggest additional problems in consolidation of newly learned information into permanent memory in RD. To explore this hypothesis, we will employ integrated brain/behavior analyses to examine both online learning and offline consolidation of newly learned O, P and S forms. To examine neural mechanisms underlying consolidation deficits more precisely we will also use targeted linguistic and non-linguistic learning tasks that systematically modulate demands on procedural vs. declarative memory systems. For all of these language and non-linguistic measures of learning and consolidation we test specific brain-based models of TD/RD differences. PUBLIC HEALTH RELEVANCE: The proposed study will to use multiple neuroimaging methods to test predictive models of individual differences in learning consolidation for: 1) novel spoken and written word learning tasks that vary in demands on component processes relevant to reading, and 2) language and nonlinguistic tasks that systematically examine contributions from those cortical and subcortical neural systems associated with procedural and declarative memory as a window on basic learning and consolidation deficits in reading disability (RD). The overarching goal is to develop causal models of the ways in which any one, or some combination of, these functional and structural factors might act to impede language and reading-related skill acquisition in RD.