Neurobiological Foundations of reading (dis)ability

阅读(失能)能力的神经生物学基础

基本信息

  • 批准号:
    7230955
  • 负责人:
  • 金额:
    $ 55.56万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2005
  • 资助国家:
    美国
  • 起止时间:
    2005-08-01 至 2010-05-31
  • 项目状态:
    已结题

项目摘要

DESCRIPTION (provided by applicant): The proposed longitudinal study is designed to examine reading development at critical points in its establishment (from ages 7.5-10.5) in nonimpaired (Nl) and reading disabled (RD) cohorts. Our previous cross sectional research has identified reading group differences in both functional neuroanatomical and behavioral trajectories; the proposed longitudinal study is aimed at gaining a better understanding of behavioral, neurobiological, and genetic etiological factors responsible for this observed divergence. We examine the hypothesis that the candidate etiological agent that might underlie variation in neurodevelopmental and behavioral trajectories is gamma-aminobutyric acid (GABA): research has shown that GABA plays a critical role in learning and memory. Accordingly, the proposed research will permit relating developmental changes in reading performance and functional neuroanatomy for reading (measured with fMRI) to GABA expression, measured with magnetic resonance spectroscopy (MRS) and genetic analyses, linking polymorphisms in the GABA family genes to GABA expression in the brain. Specifically, the research aims to: 1) Characterize concurrent relations among genetics, neurochemistry, functional neuroanatomy, and reading behavior at 2 important timepoints in reading development, 2) Investigate Nl and RD differences for each of these measures, 3) Examine subsequent developmental trajectories in Nl and RD cohorts, 4) Better characterize learning capacities and learning styles in these cohorts, 5) Develop dynamic brain/behavior phenotypes sensitive to genetic analyses, and 6) Contrast multi-level profiles and developmental trajectories in subgroups of RD.
描述(由申请人提供):拟议的纵向研究旨在检查未受损(NI)和阅读障碍(RD)队列在其建立的关键点(7.5-10.5岁)的阅读发展。我们以前的横断面研究已经确定了阅读组在功能神经解剖学和行为轨迹方面的差异;拟议的纵向研究旨在更好地了解导致这种观察到的分歧的行为,神经生物学和遗传病因学因素。我们研究的假设,可能是神经发育和行为轨迹的变化背后的候选病原体是γ-氨基丁酸(GABA):研究表明,GABA在学习和记忆中起着至关重要的作用。因此,拟议中的研究将允许相关的阅读性能和功能神经解剖学的阅读(用功能磁共振成像测量)的GABA表达,磁共振波谱(MRS)和遗传分析,GABA家族基因的多态性在大脑中的GABA表达。具体而言,该研究旨在:1)在阅读发展的2个重要时间点表征遗传学、神经化学、功能性神经解剖学和阅读行为之间的并发关系,2)调查这些测量中的每一个的NI和RD差异,3)检查NI和RD组群中的后续发展轨迹,4)更好地表征这些组群中的学习能力和学习风格,5)开发对遗传分析敏感的动态脑/行为表型,以及6)对比RD亚组中的多水平概况和发育轨迹。

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

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Kenneth R. Pugh其他文献

The Cambridge Handbook of Psycholinguistics: How Does the Brain Read Words?
剑桥心理语言学手册:大脑如何阅读单词?
  • DOI:
  • 发表时间:
    2012
  • 期刊:
  • 影响因子:
    0
  • 作者:
    R. Sandak;S. Frost;J. Rueckl;N. Landi;W. Mencl;Leonard Katz;Kenneth R. Pugh
  • 通讯作者:
    Kenneth R. Pugh
Deficient Response to Altered Auditory Feedback in Dyslexia
阅读障碍患者对听觉反馈改变的反应不足
  • DOI:
    10.1080/87565641.2018.1495723
  • 发表时间:
    2018
  • 期刊:
  • 影响因子:
    1.5
  • 作者:
    M. Bunt;Margriet A. Groen;S. W. V. D. Kleij;M. W. Noordenbos;E. Segers;Kenneth R. Pugh;Ludo Verhoeven
  • 通讯作者:
    Ludo Verhoeven
How Does the Brain Read Words
大脑如何阅读单词
  • DOI:
    10.1017/cbo9781139029377.012
  • 发表时间:
    2012
  • 期刊:
  • 影响因子:
    6.2
  • 作者:
    R. Sandak;S. Frost;J. Rueckl;N. Landi;W. Mencl;Leonard Katz;Kenneth R. Pugh
  • 通讯作者:
    Kenneth R. Pugh
Neuroimaging Studies of Reading Development and Reading Disability
阅读发展和阅读障碍的神经影像学研究
  • DOI:
  • 发表时间:
    2001
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Kenneth R. Pugh;W. Mencl;A. Jenner;Jun Ren Lee;L. Katz;S. Frost;S. Shaywitz;Bennett A Shaywitz
  • 通讯作者:
    Bennett A Shaywitz

Kenneth R. Pugh的其他文献

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{{ truncateString('Kenneth R. Pugh', 18)}}的其他基金

Tracking neurocognitive changes during evidence-based reading instruction in typically and atypically developing children
跟踪典型和非典型发育儿童的循证阅读教学期间的神经认知变化
  • 批准号:
    10698010
  • 财政年份:
    2022
  • 资助金额:
    $ 55.56万
  • 项目类别:
Tracking neurocognitive changes during evidence-based reading instruction in typically and atypically developing children
跟踪典型和非典型发育儿童的循证阅读教学期间的神经认知变化
  • 批准号:
    10402459
  • 财政年份:
    2022
  • 资助金额:
    $ 55.56万
  • 项目类别:
Tracking neurocognitive changes during evidence-based reading instruction in typically and atypically developing children
跟踪典型和非典型发育儿童的循证阅读教学期间的神经认知变化
  • 批准号:
    9384624
  • 财政年份:
    2017
  • 资助金额:
    $ 55.56万
  • 项目类别:
Tracking neurocognitive changes during evidence-based reading instruction in typically and atypically developing children
跟踪典型和非典型发育儿童的循证阅读教学期间的神经认知变化
  • 批准号:
    10207696
  • 财政年份:
    2017
  • 资助金额:
    $ 55.56万
  • 项目类别:
Tracking neurocognitive changes during evidence-based reading instruction in typically and atypically developing children
跟踪典型和非典型发育儿童的循证阅读教学期间的神经认知变化
  • 批准号:
    9981480
  • 财政年份:
    2017
  • 资助金额:
    $ 55.56万
  • 项目类别:
Neurocognitive determinants of adolescent second language literacy development
青少年第二语言读写能力发展的神经认知决定因素
  • 批准号:
    8308379
  • 财政年份:
    2011
  • 资助金额:
    $ 55.56万
  • 项目类别:
Neurocognitive determinants of adolescent second language literacy development
青少年第二语言读写能力发展的神经认知决定因素
  • 批准号:
    8687699
  • 财政年份:
    2011
  • 资助金额:
    $ 55.56万
  • 项目类别:
Neurobiological predictors of spoken and written language learning
口语和书面语言学习的神经生物学预测因子
  • 批准号:
    8450174
  • 财政年份:
    2011
  • 资助金额:
    $ 55.56万
  • 项目类别:
Neurocognitive determinants of adolescent second language literacy development
青少年第二语言读写能力发展的神经认知决定因素
  • 批准号:
    8465250
  • 财政年份:
    2011
  • 资助金额:
    $ 55.56万
  • 项目类别:
Neurobiological predictors of spoken and written language learning
口语和书面语言学习的神经生物学预测因子
  • 批准号:
    8262682
  • 财政年份:
    2011
  • 资助金额:
    $ 55.56万
  • 项目类别:

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