Novel 2'- and 3'- Branched Carbocyclic Nucleosides will be synthesized and Evalua

描述（由申请人提供）：新病毒性疾病（如HCV、SARS、西尼罗河病毒、H1N1流感）的出现、使用天花的生物恐怖主义威胁的增加以及对现有药物耐药的新病毒株的出现，保证了新药的开发。该提案的目标是发现新的抗病毒候选药物，通过修饰碳环核苷类似物来治疗此类疾病。合成的新类似物将接受针对多种病毒的抗病毒活性测试。 公共卫生相关性：该提案的目标是发现新的抗病毒候选药物，以治疗新的病毒性疾病，如HCV，SARS，西尼罗河病毒，H1N1流感和生物恐怖主义剂天花。拟议的研究项目还侧重于通过修饰一种碳环核苷类似物来开发对现有药物具有耐药性的病毒株的新药。

DESCRIPTION (provided by applicant): The emergence of new viral diseases such as HCV, SARS, West Nile virus, H1N1 influenza, increased threat of bioterrorism using smallpox and appearance of new viral strains resistant to existing drugs warrants development of new medications. The goal of this proposal is to discover new antiviral candidates to treat such diseases by modifying a lead carbocyclic nucleoside analog. New analogs synthesized will be tested for antiviral activity against a wide array of viruses. PUBLIC HEALTH RELEVANCE: The goal of this proposal is to discover new antiviral candidates to treat new viral diseases such as HCV, SARS, West Nile virus, H1N1 influenza, and bioterrorism agent smallpox. The proposed research project also focuses on the development of new medications to viral strains resistant to existing drugs by modifying a lead carbocyclic nucleoside analog.