Novel antioxidant therapeutics for sulfur mustard toxicity (U54)

该示意图说明了化学生物防御组的组织结构，这是一个协作小组 国家犹太医学研究中心和科罗拉多大学丹佛健康分校 科学中心。行政核心由卡尔·W·怀特医学博士领导，加布里埃尔·切瑟姆担任 行政助理。教育核心将提供一年一度的为期一天的医疗保健研讨会 关于化学生物防御主题的专业人员、生物医学研究人员、学员和学生，以及2- 每年3位杰出教授，他们将就这一或密切相关的研究领域进行演讲。科学的 工作组的努力包含在三个基本和翻译项目(项目1、2和3)和一个 曝光核心。该小组的研究重点是硫磺芥末对肺部和皮肤的毒性。这个 模型化合物2-氯乙基乙基硫化物(CEES；“半芥末”，一种毒性较低的硫磺芥末类似物) 在这里提议的研究中使用。

This schematic illustrates the organization of the Chemical Biodefense Group which is a collaborative group of the National Jewish Medical and Research Center and the University of Colorado at Denver Health Sciences Center. The Administrative Core is headed by Carl W. White, M.D., with Gabriele Cheatham as Administrative Assistant. The Educational Core will provide an annual day-long workshop for health care professionals, biomedical researchers, trainees and students on the topic of chemical biodefense, along with 2- 3 Distinguished Professors annually who will lecture on this or closely aligned research areas. The scientific efforts of the group are contained in three basic and translational projects (Projects 1, 2, and 3) and an Exposure Core. The focus of the group's research is sulfur mustard toxicity in the lung and skin. The model compound 2-chloroethyl-ethyl sulfide (CEES; "half-mustard," a less toxic analog of sulfur mustard) will be used in the studies proposed here.