HYPOXIA-INDUCIBLE FACTORS IN BPD

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 具体目标： (1)比较低氧和常氧对胎肺和新生肺组织中HIF、HIF相关基因表达和血管生长相关蛋白活性的影响，并观察体外抑制HIF蛋白PHD对这些活性的影响。 (2)体内检测PHD抑制对HIF蛋白、HIF相关基因产物和血管生长相关激酶活性的影响。 (3)评价PHD抑制对肺功能、气体交换、血管和肺泡发育的影响。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Specific aims: (1) Compare effects of hypoxia and normoxia in fetal and newborn lung tissue as to HIFs, HIF-related gene expression, and vascular growth-related kinase activities, and to evaluate the in vitro effect of HIF prolyl hydroxylase domain-containing proteins PHD inhibition on these activities. (2) Examine the effect of PHD inhibition on HIF proteins, HIF-related gene products, and vascular growth-related kinase activities in vivo. (3) Evaluate the effect of PHD inhibition on pulmonary function, gas exchange, and vascular and alveolar development