Progenitor Cell Biology Consortium Administrative Coordinating Center

描述(由申请人提供)： 通过移植再生人类骨髓现在在美国是一种常见的医学实践。虽然在人类心脏组织和肺组织中已经发现了干细胞，但关于这些组织和骨髓中的干细胞和祖细胞生物学仍有许多需要了解的地方。一个联合体(NHLBI祖细胞生物学联合体)可以利用最近的发展(发现、技术和试剂)来鉴定和表征祖细胞谱系，指导干细胞和祖细胞的分化，并解决这些细胞移植的挑战，将其转化为再生生物学和医学设施中的治疗方法。为了实现其目标，应用干细胞和祖细胞生物学的进展来促进心血管、肺和血液疾病的识别，行政协调中心(ACC)是必要的。拟议的ACC拥有知识渊博和经验丰富的教职员工，并计划为NHLBI前体细胞生物学联盟提供出色的行政和技术支持。拟议的行政协调会在组织会议和电话会议方面有着良好的记录，并将组织会议和电话会议，维护书面文件和网站，授予分包合同，监督试点和辅助研究基金的审查和授予，并处理这些研究、续签和报告。拟议的行政协调会的传播和教授(教学)优势将加强技能发展活动的协调。通过将祖细胞生物学研究人员及其数据的合作小组聚集在一起，组织沟通和信息，并传播研究结果，ACC将为NHLBI祖细胞生物学联盟的成功做出重要贡献。

DESCRIPTION (provided by applicant): The regeneration of human bone marrow from transplantation is now a common medical practice in the United States. Although stem cells resident in cardiac tissues and pulmonary tissues have been identified in humans, much remains to be learned about stem cell and progenitor cell biology in these tissues and in the bone marrow. A Consortium (the NHLBI Progenitor Cell Biology Consortium) could take advantage of recent developments (discoveries, technologies and reagents) to Identify and characterize progenitor cell lineages, to direct the differentiation of stem and progenitor cells and to address the challenges of transplanting those cells to translate into treatments in the regenerative biology and medicine armamentarium. An Administrative Coordinating Center (ACC) is necessary for this Consortium to achieve its goals of applying advances in stem and progenitor cell biology to advance the identity of cardiovascular, lung and blood diseases. The proposed ACC has the knowledgeable and experienced faculty and staff and a plan to provide outstanding administrative and technical support to the NHLBI Progenitor Cell Biology Consortium. The proposed ACC has a strong track record in and will organize meeting and conference calls, maintain written documents and a website, award subcontracts, oversee review and award of pilot and ancillary study funds, and process those studies, renewals and reports. The communications and professorial (instructional) strengths of the proposed ACC will enhance coordination of skills development activities. By bringing together collaborating groups of progenitor cell biology investigators and their data, organizing communications and information, and disseminating findings, the ACC will make an important contribution to the success of the NHLBI Progenitor Cell Biology Consortium.