Impact of maternal and perinatal feeding of enzymatically hydrolyzed yeast cell walls on growth performance and immunocompetence in piglets and broiler chicks

监管机构、生产者和消费者为消除使用抗生素来提高生长性能而采取的行动更加重视优化性能的替代策略。由于新生仔猪和雏鸡的消化和免疫系统尚不成熟，其顺利过渡到生产环境对终生的生物学和经济性能有着巨大的影响。本研究的首要目标是研究水解酵母细胞代谢产物在整合母体和围产期营养以增强新生仔猪和雏鸡免疫能力方面的效用。母猪和种鸡将分别饲喂酶水解的酵母细胞，以刺激乳汁和孵化卵中免疫球蛋白的沉积。酵母细胞壁代谢产物不仅可以增强新生儿的免疫能力，而且还有利于将有益和特异性的微生物群转移到下一代。在幼龄动物中证明增强的免疫能力和有利的微生物演替将导致在没有预防性抗生素的情况下在动物蛋白质生产的背景下饲养和管理育种动物的新方法。该项目将采用各种实验，统计和分析技术，从而为HQP提供极好的培训机会。具体而言，该研究项目将支持2名博士和2名本科生以及一名技术人员的培训。

The actions taken by regulatory bodies, producers, and consumers to eliminate the use of antibiotics for growth performance are placing greater emphasis on alternative strategies for optimizing performance. Because of immature digestive and immune systems, smooth transition of neonatal piglets and chicks to production environment has huge impact on lifetime biological and economic performance. The overriding goal of this research is to investigate the utility of hydrolyzed yeast cell metabolites in integrating the dam and perinatal nutrition to enhance immunocompetence of neonatal piglets and chicks. Sows and breeders will be fed enzymatically hydrolyzed yeast cell to stimulate deposition of immunoglobulins in milk and hatching eggs, respectively. Yeast cell wall metabolites may not only enhance immunocompetence of the neonate but also favor the beneficial and specific microbiota to be transferred into the next generation. Demonstrating enhanced immunocompetence and favorable microbial succession in young animals will lead to new approaches for feeding and managing breeding animals in the context of animal protein production without preventative antibiotics. The project will employ a variety of experimental, statistical, and analytical techniques thus providing excellent training opportunities for HQP. Specifically, the research project will support training of 2 Ph.D and 2 undergraduate students, and a technician.