Administrative Core

项目总结(见说明)： 管理五项核心计划的总体目的是确保该计划在科学、组织和运作方面的卓越表现，并确保其有能力实现NIEHS的科学里程碑和目标。该核心将负责PNNL工程纳米材料毒性计划的总体组织结构、管理活动和财务责任，并将确保所有研究在诚信的情况下进行，并在适当的环境、安全和健康考虑和规划下进行。 这些责任将通过以下目标完成： 1)为决策过程、研究活动的规划、方案资金的有效管理和资源分配提供管理和行政支持结构； 2)促进研究项目和本计划内的研究核心之间的跨学科互动和协调，包括材料合成和材料表征； 3)协调跨研究项目和计划内研究核心的实验数据的统计分析和建模；以及4)确保与NIEHS和更广泛的NIEHS纳米毒理学研究联盟进行有效的联系。 AdmlnistraFive核心还将对跨项目、生物系统的数据集成所需的生物统计资源和活动进行监督和优先排序，并保持对整个方案目标的重点，即为工程设计的危险识别和风险评估开发新的方法 纳米材料。

PROJECT SUMMARY (See instructions): The overall purpose of the Admlnistrafive Core is to ensure scientific, organizational and operational excellence ofthe Program and its ability to meet scientific milestones and objectives ofthe NIEHS. The Core will be responsible for overall organizational structure, administrative activities and fiscal responsibilities of the PNNL's Program for the Toxicity of Engineered Nanoniaterials, and will ensure all research is conducted with integrity and with appropriate environmental, safety and health considerations and planning. These responsibilities will be accomplished by the following Aims: 1) Provide a management and admlnistrative support structure for decision-making processes, planning of research activities, and efficient management of program funds, and resource allocation with the Program; 2) Promote cross-disciplinary interactions and coordination among the research projects and the research core within the Program, including material synthesis and materials characterization; 3) Coordinate statistical analysis and modeling of experimental data across research projects and the research core within the Program; and 4) Ensure effecfive liaison with NIEHS and the broader NIEHS nanotoxicology research consortium. The Admlnistrafive Core will also provide oversight and prioritization of biostatistical resources and activities needed for data integration across projects, biological systems, and to maintain focus of the overall Program goals of developing novel approaches for hazard identificafion and risk assessment for engineered nanomaterials.