UCLA Institute for Molecular Medicine (IMED) Core

三个核心资源设施，支持NSBCC项目的描述。 IMED核心#1位于加州大学洛杉矶分校，旨在为我们更先进的技术平台向更大（当地）肿瘤学社区的翻译提供项目支持和能力，从而扩大我们最强大的纳米技术的影响力IMED核心完全集成到加州大学洛杉矶分校分子医学研究所（IMED）。IMED旨在支持转化医学项目 无论是在中央NSBCC的努力之内还是之外。该核心还包含我们关键的体内分子成像基础设施，并提供成像培训和NSBCC翻译技术培训。 更大的IMED设施的专用空间配备了一套工具，旨在为特定的转化医学项目定制NSBCC体外诊断技术，包括用于制备和纯化关键NSBCC纳米/生物材料的工具，蛋白质生物标志物定制面板的开发，以及表面定制工具。NSBCC核心设施旨在充分利用 更大的UCLA IMED转化医学设施以及利用该设施的癌症研究人员和临床医生社区。 另外两项核心资源专门用于技术开发。NSBCC项目由癌症生物学和癌症患者治疗的基础和临床问题驱动。因此，我们的最终交付成果大体上是与生物内容（例如一组蛋白质生物标志物）相结合的技术平台（例如一种体外诊断芯片）。纳米纤维和 加州理工学院的nanotenals表征核心#2旨在支持NSBCC活动，范围从纳米技术和微流体平台的快速原型设计，纳米材料合成和表征，表面科学和技术平台规模扩大。系统生物学研究所的系统生物学核心#3旨在支持基因组学，转录组学和蛋白质组学工作，以及 计算生物学和数据库挖掘和开发，为我们可交付成果中的大部分生物内容提供基础支持。

Three Core Resources facilities that support NSBCC Projects are described. The IMED Core #1, is located at UCLA, and is designed to provide project support and capability for the translation of our more advanced technology platforms to the greater (local) oncology community, thus expanding the influence of our most robust nanotechnologies The IMED core is wholly integrated into the UCLA Institute for Molecular Medicine (IMED). IMED is designed to support translational medicine projects both within and outside of the central NSBCC effort. This core also contains our key in vivo molecular imaging infrastructure and provides training for imaging and training on NSBCC technologies for translation. A devoted space with the larger IMED facility has been equipped with a suite of tools designed to customize NSBCC in vitro diagnostic technologies for specific translational medicine projects, including tools for the preparation and purification of key NSBCC nano/bio materials, the development of custom panels of protein biomarkers, and tools for surface customization. That NSBCC core facility is designed to fully leverage off of the much larger UCLA IMED translational medicine facility as well as the community of cancer researchers and clinicians that utilize that facility. The other two core resources are devoted to technology development. The NSBCC projects are driven by fundamental and clinical problems in cancer biology and the treatment of cancer patients. As such, our ultimate deliverables are, by and large, technology platforms (e.g. an in wfro diagnostic chip) that are combined with biological content (e.g. a panel of protein biomarkers). The nanofabrication and nanomatenals characterization core #2 at Caltech is designed to support NSBCC activities that range from rapid prototyping of nanotech and microfluidics platforms, nanomaterials synthesis and characterization, surface science, and technology platform scale-up. The systems biology core #3 at the Institute for Systems Biology is designed to support the genomics, transcriptomics, and proteomics work, as well as the computational biology and data base mining and development that provides the base support for much of the biological content within our deliverables.