IMPORTANCE OF MONOCYTES/MACROPHAGES IN AIDS

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 人们普遍认为，CD 4（+）T细胞的破坏和病毒载量是HIV-1感染的人类和猴免疫缺陷病毒（SIV）感染的猕猴免疫缺陷的主要标志。然而，单核细胞/巨噬细胞也是HIV/SIV感染的重要靶点，并且是先天免疫和适应性免疫之间的关键环节。因此，我们研究了单核细胞/巨噬细胞谱系细胞的变化是否与恒河猴模型中艾滋病的发病机制有关。在这里，我们表明，大量的营业额外周血单核细胞与死亡的组织巨噬细胞与艾滋病的进展在猕猴。更重要的是，单核细胞更新水平与CD 4（+）T细胞计数无关，并且是比病毒载量或淋巴细胞活化更好的预测AIDS进展的标志物。我们的研究结果表明单核/巨噬细胞在艾滋病发病机制中的重要性，并建议单核/巨噬细胞的动态变化作为一个新的标志艾滋病的进展。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. It is widely accepted that destruction of CD4(+) T cells and viral load are the primary markers for immunodeficiency in HIV-1-infected humans and in simian immunodeficiency virus (SIV)-infected macaques. However, monocyte/macrophages are also important targets of HIV/SIV infection and a critical link between innate and adaptive immunity. We therefore examined whether changes in cells of the monocyte/macrophage lineage could be linked to the pathogenesis of AIDS in the rhesus macaque model. Here, we show that massive turnover of peripheral monocytes associated with death of tissue macrophages correlates with AIDS progression in macaques. More importantly, the level of monocyte turnover was not linked to the CD4(+) T-cell count and was a better predictive marker for AIDS progression than was viral load or lymphocyte activation. Our results show the importance of monocyte/macrophages in the pathogenesis of AIDS and suggest the dynamic changes of the monocyte/macrophages as a new marker for AIDS progression.