Conversion agricultural waste to nanomedicine for bone regeneration

全球不断增长的老年患者人口正在导致与骨质疏松相关的骨折增加。在北美，预计每两个50岁以上的人中就有一个有患髋部骨质疏松症的风险，这主要是由于老龄化和骨质疏松症的流行，这可能会加速对骨植入物的需求。尽管近年来研究取得了进展，但骨科植入物的寿命有限，而且往往由于骨整合不足而失败。因此，通过提高成骨能力来促进种植体内的骨整合是非常必要的。纳米结构被认为具有推动骨再生领域的突破性潜力。申请者的研究团队专门开发使用高重复频率飞秒激光的纳米材料制造。该团队成功地从稻壳/稻草和蛋壳中合成了三维纳米结构。在这个项目中，他们将与威斯康星大学密尔沃基分校(UWM)的教师合作，探索将纳米结构应用于骨再生药物的可行性。Ryerson的团队开发制造策略来调整纳米结构的物理化学和生物学特性，而UWM的团队将研究创新纳米材料的生物兼容性、它们与间充质细胞的相互作用策略，以及植入体内时对纳米材料的免疫反应。这项合作的长期目标是开发一种将农业废物转化为高度有益的医疗发明的技术。这项研究在卫生保健、环境、经济和社会背景下对加拿大都是有益的。

Growing geriatric patient populations around the globe are leading to increased osteoporosis-related fractures. In North America one in two over age 50 is anticipated to be at risk of developing hip osteoporosis mostly due to aging and the prevalence of osteoporosis, which will likely accelerate demand for bone implants. Although research progress has been made in recent times, orthopedic implants have a limited lifespan and often fail due to low osseointegration. Hence it is essential to facilitate osseointegration in implants by enhancing the ability of osteogenesis. It is believed that nanostructures have the breakthrough potential to propel the field of bone regeneration. The applicant's research team specializes in developing nanomaterial fabrication using high repetition rate femtosecond lasers. The team has successfully synthesized three-dimensional nanostructure from rice husk/straw and eggshells. In this project, they will collaborate with faculty from University of Wisconsin at Milwaukee (UWM) to explore the feasibility of applying the nanostructure as medicine for bone regeneration. While the team at Ryerson develops the fabrication strategy to tune the physiochemical and biological properties of the nanostructure, the team at UWM will study the biocompatibility of the innovative nanomaterial, their interaction strategies with mesenchymal cells, and immune response to the nanomaterial when implanted in body. The long-term goal of this collaboration is to develop a technique to convert agricultural waste to a highly beneficial medical invention. This research is beneficial to Canada in health care, environmental, economic, and social contexts.