Research Administration Core, Human DNA Samples Bank, Animal Models, & Databases

项目A 少年派：伊曼纽尔·米诺特 标题：研究管理核心，人类DNA样本库，动物模型和数据库 描述(由申请人提供)：一支经验丰富且训练有素的研究管理人员对于有效管理一个复杂的多学科项目至关重要。在该项目连续18年的资助期间，睡眠研究中心的首席研究员和助理主任共同努力，建立了一支由研究管理员和研究支持人员组成的团队，负责管理发作性睡病中心的日常活动。这包括预算和财务报告规划、政策和指导方针的监督、动物和人体数据库管理、受试者招募以及将该项目整合到睡眠研究中心和睡眠诊所，以及总体上确保该计划顺利运行。为了支持这项修订后的研究提案，我们确认了五项主要核心活动：1)研究行政和协调职能，以促进研究人员和项目之间的研究和互动；2)本提案中使用的斯坦福大学嗜睡症动物群体中心的管理；这包括斑马鱼、小鼠和大鼠。3)为研究项目招募人类发作性睡病患者：包括收集发作性睡病患者和对照受试者的DNA、血清、脑脊液和脑标本。4)维护包含人类、小鼠/大鼠、犬类发作性睡病数据和组织样本数据的计算机化数据库；维护项目网站和在线数据共享。5)维护支持遵守所有联邦指导方针和政策进行研究的所有文件。首席调查员有责任确保发作性睡病科学家中心作为一个综合团队开展工作。他的指导和科学领导，对于追求该计划的总体目标至关重要。每周举行一次研究会议，以促进研究人员之间以及研究人员和研究行政人员之间的沟通。

PROJECT A PI: Emmanuel Mignot Title: Research Administration Core, Human DNA Samples Bank, Animal Models, & Databases Description (provided by applicant): A seasoned and well-trained research administration staff is essential for the effective management of a complex multi-disciplinary program project. During the last consecutive 18 years of funding of this program project the Principal Investigator and the Assistant Director of the Sleep Research Center have worked together and built a team of research administrators and research support staff that are responsible for the day-to-day activities of managing the Center for Narcolepsy. This includes budgetary and fiscal reporting planning, oversight of policy and guidelines, animal and human database management, subject recruitment and the integration of this project into the Sleep Research Center and Sleep Clinic, and in general ensuring that the program runs smoothly. To support this revised research proposal, five main core activities are recognized: 1) A research administrative and coordinating function to facilitate the research & interactions among investigators and projects 2) Management of the Stanford University Center for Narcolepsy animal colonies used in this proposal; this includes zebrafish, mice, and rats. 3) Recruitment of human narcolepsy patients for research projects: this includes the banking of DNA, serum, cerebrospinal fluid and brain specimens from narcolepsy and control subjects. 4) Maintenance of computerized databases containing human, mouse/rat, canine narcolepsy data and tissue sample data; maintenance of the project's website and data-sharing on-line. 5) Maintenance of all documentation supporting adherence to all federal guidelines and policies for conducting research. It is the responsibility of the Principal Investigator to assure that the Center for Narcolepsy scientists work as an integrated team. His direction and scientific leadership, is essential to the pursuit of the overall goals of the program. A weekly research meeting is held to facilitate communication among the investigators and between the research staff and research administration staff.