Probabilistic Control of Functional Electrical Stimulation

描述(申请人提供)：功能性电刺激包括用植入的电极人工激活瘫痪的肌肉，并已成功地用于提高四肢瘫痪患者执行日常活动重要动作的能力。然而，功能性电刺激可以产生的运动行为范围仅限于相对较小的一组预先编程的动作，如握手和松开。尚未实施更广泛的运动，因为在确定引起特定运动所需的肌肉刺激模式方面存在重大挑战。我们计划使用一种概率算法来根据手的轨迹信息预测与广泛的上肢运动相关的肌肉活动模式。然后，肌肉活动的预测模式将被转换为幅度调制的脉冲序列，并用于驱动肌肉刺激器，以便在暂时瘫痪的动物中唤起运动。将诱发的动作与期望的动作进行定量比较，以评估该方法的整体效果。最终，这种概率方法可以作为脑源性轨迹信息和现有功能电刺激系统之间的必要接口，实现一个自给自足、自我控制的上肢神经假体系统。这样一个集成和灵活的系统将极大地提高瘫痪个体的运动能力和独立性。该项目的目标是开发一种新的方法，通过在肌肉中植入电极来人工激活和控制瘫痪的肌肉。这一努力将有助于恢复因脊髓损伤或中风而瘫痪的个人的自主肢体运动。该项目的目标是开发一种新的方法来人工激活和控制 在肌肉中植入电极的瘫痪肌肉。这一努力将有助于 脊髓瘫痪患者肢体自主运动功能的恢复 受伤或中风。

DESCRIPTION (provided by applicant): Functional electrical stimulation involves artificial activation of paralyzed muscles with implanted electrodes and has been used successfully to improve the ability of quadriplegics to perform movements important for daily activities. The range of motor behaviors that can be generated by functional electrical stimulation, however, is limited to a relatively small set of preprogrammed movements such as hand grasp and release. A broader range of movements has not been implemented because of the substantial challenge associated with identifying the patterns of muscle stimulation needed to elicit specified movements. We plan to use a probabilistic algorithm to predict the patterns of muscle activity associated with a wide range of upper limb movements based on hand trajectory information. The predicted patterns of muscle activity will then be transformed into amplitude-modulated trains of pulses and used to drive muscle stimulators in order to evoke movements in temporarily paralyzed animals. The evoked movements are quantitatively compared to the desired movements to evaluate the overall effectiveness of this approach. Ultimately, this probabilistic method could serve as the requisite interface between brain-derived trajectory information and existing functional electrical stimulation systems to realize a self-contained and self-controlled upper limb neuroprosthetic system. Such an integrated and flexible system would greatly increase movement capability, and independence, in paralyzed individuals. The goal of this project is to develop a new method to artificially activate and control paralyzed muscles with electrodes implanted in muscles. This effort will contribute to the restoration of voluntary limb movements in individuals paralyzed because of spinal cord injury or stroke. The goal of this project is to develop a new method to artificially activate and control paralyzed muscles with electrodes implanted in muscles. This effort will contribute to the restoration of voluntary limb movements in individuals paralyzed because of spinal cord injury or stroke.