Pediatric Rheumatology Research Annual Scientific Meeting

描述（由申请人提供）：儿科流变学研究年度科学会议将是儿科流变学社区分享最先进的科学方法，科学机会和新技术的论坛。该提案是对我们先前为支持2012年、2013年、2014年、2015年和2016年会议提供的会议赠款的延续。这些会议将由儿童关节炎和风湿病研究联盟（CARRA）共同赞助，CARRA是一个由美国和加拿大大多数儿科风湿病学家组成的研究网络。这些会议预计将持续2天半，CARRA的所有成员，儿科风湿病社区，对儿科风湿病研究感兴趣的个人将被邀请参加，以及相关领域（内科风湿病，免疫学，流行病学和其他儿科研究网络）的特邀演讲者和专家。在2012年，2014年和2016年会议为期一天的研讨会称为“临床研究的要点”将在2天半的科学年会之前举行。为期一天的研讨会将提供教学和互动会议的混合作为一个治疗医生和PI之间的紧张关系，IRB的作用，同意书和同意过程，不良事件报告，优化研究启动，招募和保留，监测研究，研究中心的责任，研究药物处理，方案审查，以及研究中心预算和合同。2013年和2015年的会议将是为期2天和1/2天的科学会议，有更多时间制定每个主要疾病领域的方案。所有会议将有一个混合的教学会议的翻译主题相关的儿科风湿病和临床研究方法，并制定协议的时间。促进互动会议将确定每个主要疾病领域的关键研究需求和机会，并制定未来发展为具体研究项目的科学优先事项。将确定和培养合作机会和指导关系，并与临床研究问题协调确定转化研究机会。本次会议的目标是：1。提高我们对儿童风湿性疾病发病机制（免疫、遗传、表观遗传和炎症）、流行病学以及当前和创新治疗方法的理解; 2.为儿科风湿病学研究社区提供一个合作和指导的发展论坛，特别关注年轻的研究者; 3。提供与临床儿科风湿病学研究和临床研究实施相关的主要领域的培训和教育。4.将儿科风湿病研究协调员纳入CARRA研究战略的推进和具体研究项目的开发。此次会议将是CARRA实现其主要使命的主要途径之一，即促进高质量研究的发展，并最终创建一个研究组合，其中包括每种类型的儿科风湿病的相关研究项目。 公共卫生相关性：儿科风湿病研究年度科学会议是促进和促进儿科风湿病研究的关键，因为儿科风湿病绝对需要合作和科学交叉施肥。儿科风湿性疾病家族（包括幼年特发性关节炎、系统性红斑狼疮、幼年皮肌炎、硬皮病和血管炎）是儿童最常见的慢性疾病，其发生率与幼年1型糖尿病相当。本次会议是美国和加拿大儿科风湿病学的主要场所，用于确定重要的研究问题，并开发高质量，精心构思的研究来回答这些问题，并最终改善受儿科风湿性疾病影响的儿童的健康结果。

DESCRIPTION (provided by applicant): The Pediatric Rheumatology Research Annual Scientific Meeting will be the forum for the pediatric rheumatology community for sharing the scientific state-of-the-art methodologies, scientific opportunities and new technologies. This proposal is a renewal of our previous conference grant to support meetings in 2012, 2013, 2014, 2015 and 2016. These meeting will be co-sponsored by the Childhood Arthritis and Rheumatology Research Alliance (CARRA), a research network comprising the majority of pediatric rheumatologists in the US and Canada. These meetings are conceived to be 2 1/2 days and all members of CARRA, the pediatric rheumatology community, individuals interested in pediatric rheumatic disease research will be invited to attend as well as invited speakers and experts in related fields (internal medicine rheumatology, immunology, epidemiology, and other pediatric research networks). In 2012, 2014 and 2016 meeting a one day workshop called 'Essentials of Clinical Research' will be held preceding the 2 & 1/2 day scientific annual meeting.. The one day workshop will offer a mix of didactic and interactive sessions on the tension between being a treating physician and PI, role of the IRB, consent forms and consenting process, adverse event reporting, optimizing study start up, recruitment and retention, monitoring of studies, site responsibilities, investigational drug handling, protocol review, and site budgeting and contracts. The 2013 and 2015 meetings will be 2 & 1/2 day scientific meetings with more time for protocol development in each major disease area. All meetings will have a mix of didactic sessions on translational topics relevant to pediatric rheumatologic diseases and clinical research methodology, and time for development of protocols. Facilitated interactive sessions will identify the key research needs and opportunities in each of the major disease area, with development of the scientific priorities for future development into specific research projects. Collaborative opportunities and mentoring relationships will be identified and fostered, and translational research opportunities will be identified in coordination with clinical research questions. The objectives of this meeting are to: 1. To advance our understanding of the pathogenesis (immune, genetic, epigenetic and inflammatory), epidemiology, and current and innovative therapeutic approaches in pediatric rheumatic diseases; 2. Provide a forum for development of collaborations and mentoring for the pediatric rheumatology research community with special attention to young investigators; 3. Provide training and education in major areas relevant to clinical pediatric rheumatology research and the conduct of clinical research. 4. To integrate pediatric rheumatology research coordinators into the advancement of the CARRA research strategy and the development of specific research projects This meeting will be one of the major avenues whereby CARRA will achieve its primary mission of facilitating the development of high-quality research studies and ultimately creating a research portfolio that includes relevant research projects in every type of pediatric rheumatic disease. PUBLIC HEALTH RELEVANCE: The Pediatric Rheumatology Research Annual Scientific Meeting is key to fostering and facilitating research in pediatric rheumatic diseases because of the absolute need for collaboration and scientific cross-fertilization in pediatric rheumatology. The family of pediatric rheumatic diseases (including juvenile idiopathic arthritis, systemic lupus erythematosus, juvenile dermatomyositis, scleroderma, and vasculitis) are among the most common chronic diseases of children comparable in occurrence to juvenile Type 1 Diabetes. This meeting is the major venue in pediatric rheumatology in the US and Canada for identifying the important research questions and developing high-quality, well-conceived studies to answer these questions and ultimately improve the health outcomes of children affected by pediatric rheumatic diseases.