Training of the Pediatric Physician-Scientist

描述(由申请人提供)：这是华盛顿大学医学院儿科医生NICHD机构培训补助金(T32 HD043010儿科医生-科学家培训)的首次竞争性续签申请。我们的长期目标是利用这笔资金促进儿科年轻内科科学家的职业发展，他们将成为致力于儿童健康的生物医学研究工作的未来领导者。这项提议的具体目的是在完成住院医师培训时或在研究金培训期间确定潜在的受训者，并向他们提供三年的实验室研究经验，由合格的导师指导，避免承担临床和教学责任，并有与儿科相关的具体研究重点。在最初的筹资期间，资助了10名优秀候选人(包括7名妇女和1名代表不足的少数群体)。我们的长期目标和具体目标在此次续签申请中保持不变；然而，我们通过两条途径(基础科学和临床/转化科学)的发展显著扩大了我们计划的范围。我们将通过应用遗传和基因组科学的最新进展来了解儿科领域内广泛疾病的发病机制和治疗，从而实现我们的长期目标。为了实现这一目标，我们将结合华盛顿大学医学院及其儿科系已有的研究力量领域。我们现在已经纳入了一个新的重点领域(路径B)，即临床和转译基因组医学，其中包括遗传流行病学、生物统计学和以患者为中心的研究。我们的计划最终将缩小基础生物学家和儿科临床医生之间的差距。我们已经建立了一个结构，在这个结构中，聪明、积极、年轻的儿科医生应该在受保护的环境中茁壮成长，并将成为不断发展的儿科领域的领导者。艾伦·施瓦茨，医学博士，医学博士将继续担任私人助理，乔纳森·D·吉特林，医学博士和迈克尔·德鲍恩，医学博士，医学硕士将继续担任联合项目主任。该项目(通过该奖项和华盛顿大学医学院的配套资金)利用了34名资深研究人员的优势，他们将担任我们学员的导师。该计划的长期目标将随着其受训人员在未来20年或更长时间内为儿科医生-科学家的发展和领导力做出贡献而实现。

DESCRIPTION (provided by applicant): This is a revised application for the first competing renewal for the NICHD Institutional Training Grant for Pediatricians (T32 HD043010 Training of the Pediatric Physician-Scientist) at Washington University School of Medicine. Our long-term objective is to utilize this funding to promote the career development of young pediatric physician scientists who will become the future leaders in the biomedical research efforts dedicated to child health. The specific aims of this proposal are to identify potential trainees at the completion of their residency training or in the midst of fellowship training and to provide them with a three year research experience in the laboratory of a qualified mentor, protected from clinical and teaching responsibilities and with a specific research focus relevant to pediatrics. During the initial funding period ten excellent candidates were supported (including seven women and one under-represented minority). Our long-term objective and specific aims remain unchanged in this renewal application; however, we have significantly expanded the scope of our program with the development of two pathways (basic science and clinical/translational science). We shall achieve our long-term objective by applying the recent advances in genetic and genomic sciences to an understanding of the pathogenesis and treatment of a broad spectrum of diseases within the Pediatric arena. In order to accomplish this we shall combine the established areas of investigative strengths of the Washington University School of Medicine and its Department of Pediatrics. We have now incorporated a new area of emphasis (Pathway B), namely clinical and translational genomic medicine which includes genetic epidemiology, biostatistics, and patient oriented research. Our program will ultimately close the gap between basic biologists and pediatric clinicians. We have in place a structure in which bright, motivated, young pediatricians shall flourish in a protected environment and will emerge as leaders in an evolving area of Pediatrics. Alan L. Schwartz, Ph.D., M.D. will continue to serve as P.I. and Jonathan D. Gitlin, M.D. and Michael DeBaun, M.D., M.P.H. will continue as co-Program Directors. The program (via this award and matched funds from Washington University School of Medicine) takes advantage of 34 established investigators who will serve as mentors to our trainees. The long-term goals of the program will be realized as its trainees contribute to the development of and leadership as pediatric physician-scientists during the next two or more decades.