Cellular and molecular foundations of biomedical science

描述（由申请人提供）：此培训补助金提案的标题为“生物医学科学的细胞和分子基础”。这是六年前开始的一个成功项目的更新，旨在培养研究生生物医学科学的广泛基础知识，为他们提供了解现代生物学和健康重要问题的工具。这最初是通过两个学期的核心课程，涵盖遗传学，基因组学和生物信息学，真核分子生物学，分子生物物理学，蛋白质结构和功能，以及细胞生物学。学生遵循这一点，在他们感兴趣的特定领域的选修课。这个跨部门的计划是基于生物科学系，但已扩大到包括从哥伦比亚的内科医生和外科医生学院建立教师。学生在多达三个实验室进行轮换，并可以在该计划的47个教师中的任何一个进行论文工作，其中大约一半在医学院校园内。这为学生在优秀实验室的培训提供了更多的机会，并促进了哥伦比亚医学院和主校区师生之间的合作。教师们在广泛的领域工作，包括结构生物学，分子生物学，遗传学，生物信息学和系统生物学，发育生物学和神经生物学。实验系统也很广泛，包括细菌、酵母、果蝇、C.线虫、青蛙和老鼠。也使用人类组织培养系统，并且大多数系统考虑与人类健康和生理学相关的问题。每年要求12个研究生培训名额，以支持6名学生，每个为期两年，通常是在他们的第三和第四年。这将资助我们目前63名符合培训补助金条件的学生中的19%。我们计划中最好的学生将被选中由这笔赠款资助。这将取决于他们在核心课程和其他课程中的表现，他们的轮换和论文赞助商的建议，以及赠款指导委员会审查的简短研究提案。哥伦比亚大学的教师和研究设施的资格是杰出的，并为学生提供了一流的培训环境。 相关性：下一代生物医学科学家的培训对于美国持续卓越的研究以及在理解，控制和治疗人类疾病方面的进步至关重要。该计划的实验室致力于解决生物医学科学中的特定基本问题，其中许多直接应用于人类疾病。

DESCRIPTION (provided by applicant): This training grant proposal is entitled "The cellular and molecular foundations of biomedical sciences". It is a renewal of a successful program started six years ago and seeks to train graduate students in the broad fundamentals of biomedical sciences to provide them with the tools to understand important problems in modern biology and health. This is accomplished initially through a two semester Core course covering Genetics, Genomics and Bioinformatics, Eukaryotic molecular biology, Molecular biophysics, Protein structure and function, and Cell biology. Students follow this with electives in specific fields of their interest. This interdepartmental program is based in the Department of Biological Sciences, but has been expanded to include established faculty from Columbia's College of Physicians and Surgeons. Students undertake rotations in up to three laboratories and can do their thesis work in any of the 47 faculty in the program, roughly half of which are on the Medical School campus. This has provided expanded opportunities for training of the students in outstanding laboratories and has fostered collaboration between faculty and students at Columbia's Medical School and main campuses. The faculty members work in a broad range of fields including structural biology, molecular biology, genetics, bioinformatics and systems biology, developmental biology and neurobiology. Experimental systems are also broad including bacteria, yeast, drosophila, C. elegans, frogs and mice. Human tissue culture systems are also utilized and most systems consider problems relevant to human health and physiology. Twelve graduate student traineeships are requested per year to support six students for two years each, usually in their third and fourth years. This will fund 19% of our current training grant eligible student pool of 63. The best students in our program will be chosen to be funded by this grant. This will be determined by their performance in the Core and other courses, recommendations from their rotation and thesis sponsors, and a short research proposal reviewed by the grant's steering committee. The qualifications of the faculty and the research facilities at Columbia are outstanding and provides a superb training environment for the students. RELEVANCE: The training of the next generation of biomedical scientists is essential to continued excellence of research in the U.S. and advances in understanding, controlling and curing human disease. Laboratories in the program address specific basic problems in biomedical sciences, many with direct applications to human disease.