Training in Trauma and Burn Research

描述（由申请人提供）：该培训计划的目标是培养年轻的研究人员在创伤科学领域进行临床应用和转化研究。该项目设在芝加哥洛约拉大学烧伤和休克创伤研究所，这是一个独特的、高度合作的研究环境，包括50多人，包括7名主要研究人员、4名额外的科学教员、5名创伤和重症护理临床专家、8名博士后研究员（医学博士和博士）、9名研究生、2名研究护士、6名研究技术人员和2名支持人员。该项目邀请住院医师和博士后申请进入为期两年的创伤学强化研究培训。该项目从2000年开始实施，目前每年招收一名新学员，下一个周期的目标是将该项目扩大到每年招收两名新学员。为招募代表性不足的少数民族制定了具体计划，其中包括我们在地方和国家两级的努力，并制定了一项全面计划，促进少数民族青年学生在中学、本科和医学院的教育和指导机会。受训者可以从7位不同的首席研究员中进行选择，他们都是创伤相关研究的经验丰富的导师，包括1)损伤后的骨髓生成改变，2)烧伤和败血症后酒精诱导的免疫变化，3)衰老中的免疫调节，4)伤口愈合和血管修复，5)酒精诱导的骨矿物质代谢和骨折愈合的变化以及6)创伤生物学中的通用素-蛋白质体系统。培训计划强调每位学员与其导师之间的密切工作关系，包括实验室研究、研讨会、期刊俱乐部、拨款写作培训以及统计学和研究生物伦理学的教学课程。所有受训者必须提交书面研究计划、正式研究报告和半年度评估。为了培养对临床问题的认识，博士学员参加选定的临床会议，并在规定的时间内参加创伤和烧伤服务的查房。我们的长期目标是增加临床医生和博士科学家的数量，他们有资格和动力共同努力解决过渡性创伤研究中的基本问题。相关性：创伤造成的生命和生产力损失是国家一级的主要社会问题之一。了解创伤学的生物学，以提高对重伤患者的护理标准，是我们减少创伤对社会的影响，从而提高国家生产力的斗争中的一个重要因素。培训未来的临床医生谁将照顾创伤患者的科学创伤生物学/将导致新的介入和治疗策略，严重受伤的病人。

DESCRIPTION (provided by applicant): The goal of this training program is to prepare young investigators to perform clinically applicable and translational research in the field of trauma science. The program is based at the Burn and Shock Trauma Institute of Loyola University in Chicago, a unique, highly collaborative research environment that includes more than 50 people, including seven principle investigators, four additional scientific faculty, five clinical specialists in trauma and critical care, eight post-doctoral fellows (both MDs and Ph.D.s), nine graduate students, two research nurses, six research technicians, and two support staff. The program solicits applications from resident physicians and post-doctoral Ph.D.s to enter a two-year period of intense research training in traumatology. The program, which has been in place since 2000, currently accepts one new trainee each year, and a goal for the next cycle is to expand the program to include the appointment of two new trainees each year. A specific plan for the recruitment of underrepresented minorities, which includes our efforts at local and national levels and a comprehensive plan to promote educational and mentorship opportunities for young minority students at school, undergraduate and medical school levels are provided. Trainees are allowed to select from among seven different principal investigators who are each experienced mentors in trauma-related research, including 1) myelopoietic alterations after injury, 2) alcohol induced immune changes following burn and sepsis, 3) immune regulation in aging, 4) wound healing and vascular repair, 5) alcohol induced changes in bone mineral metabolism and fracture healing and 6) ubiquitin- proteosome system in trauma biology. The training plan emphasizes a close working relationship between each trainee and their mentor, and includes laboratory research, seminars, journal clubs, training in grant writing, and didactic coursework in both statistics and research bioethics. Written research proposals, formal research presentations, and semi-annual evaluations are required of all trainees. To develop an appreciation for clinical problems, Ph.D. trainees participate in selected clinical conferences and attend rounds on the Trauma and Burn Services during defined periods. Our long-term goal is to increase the number of clinicians and Ph.D. scientists who are qualified and motivated to work together to address fundamental questions in transitional trauma research. RELEVANCE: Loss of life and productivity due to trauma is one of the major societal problems at the national level. Understanding the biology of traumatology to improve the standard of care of the critically injured patients is an essential element in our battle to reduce the impact of trauma on society and thus improve national productivity. Training future clinicians who will take care of trauma patients in the science of trauma biology /will lead to new interventional and therapeutic strategies to the critically injured patients.