The Cellular Biophysics of the Neuron Training Program

描述（由申请人提供）：在达拉斯（UTSW）得克萨斯大学西南医学中心的神经元培训计划（CBNTP）的细胞生物物理学将准备学员成为杰出的生物物理科学家解决复杂的神经科学问题，使用定量方法和先进的分析工具。这一领域的变革性发现将来自于科学家，他们将联合收割机对生物物理原理的深刻理解和对光学和电生理工具的透彻理解与对神经科学研究问题的深入了解结合起来。该计划的中心目标是培养能够培养细胞生物学和科学家之间协同作用的科学家，这些科学家专注于复杂的神经科学问题，包括神经系统，神经发育和神经精神疾病的细胞/分子基础。CBNTP教师在他们的研究中采用了广泛的生物物理方法，强调与人类健康，生理和疾病的相关性。CBNTP中的科学机会，从不同模型系统中神经元功能的机制分析到非神经元细胞系统中神经元相关过程的详细生物物理研究，将为培训提供独特的特殊前景。学员将获得实验生物物理学原理的最先进的专业知识，并从这些原理如何应用于高级神经科学研究的亲密接触中受益。学生将在膜生物物理学，定量分析和细胞神经生理学方面接受严格的正式培训。此外，他们将与既定的世界级榜样进行指导性互动，并从机构内外的丰富活动中受益。学生将在第三年的秋季加入CBNTP，并作为学员保留两年。培训人员的选拔具有竞争力。项目指导委员会将根据学生和导师先前的资格证书、当前的表现以及他们追求与项目研究目标一致的培训的承诺来选择学员。我们要求在第一年的2个职位，在第二年和这5年期间的每一个后续年度共4个职位。 相关性：先进生物物理方法的爆炸性增长现在几乎影响到每一个 神经科学研究的维度。通过利用定量分子和细胞生物学与神经科学家之间的相互作用，专注于神经系统，神经发育和神经精神疾病以及模型系统的工作，这种独特的培训计划为学生提供了神经科学研究中科学领导者所需的复杂技能。

DESCRIPTION (provided by applicant): The Cellular Biophysics ofthe Neuron Training Program (CBNTP) at the University ofTexas Southwestern Medical Center at Dallas (UTSW) will prepare trainees to become exceptional biophysical scientists addressing complex neuroscience questions using quantitative methods and advanced analytical tools. Transformative discoveries in this field will come from scientists who combine a deep appreciation of biophysical principles and thorough understanding of optical and electrophysiological tools with an intimate knowledge of problems in neuroscience research. The program's central goal is to train scientists who can cultivate synergistic interactions between cellular biophysicts and scientists focused on complex neuroscience problems including cellular/molecular basis of neurological, neurodevelopmental and neuropsychiatric disorders. CBNTP faculty members employ a wide range of biophysical methodologies in their research, emphasizing relevance to human health, physiology and disease. Scientific opportunities in the CBNTP ranging from mechanistic analyses of neuronal function in diverse model systems to detailed biophysical studies of neuron-relevant processes in non- neuronal cellular systems will offer uniquely exceptional prospects for training. Trainees will gain state-of-the- art expertise in experimental biophysical principals and benefit from intimate exposure to how these principles are applied in advanced neuroscience research. Students will receive rigorous formal training in membrane biophysics, quantitative analyses and cellular neurophysiology. Additionally, they will have guided interactions with established, world class role models and benefit from enrichment activities inside and outside of the institution. Students will join the CBNTP in the fall of their third year and remain as trainees for two years. Trainee selection is competitive. The program steering committee will select trainees based on prior credentials, current performance and commitment ofthe student and mentor to pursue training consistent with research goals of the program. We are requesting 2 positions in the first year, a total of 4 positions in the second and for each subsequent year of this 5-year period. RELEVANCE: Explosive growth of advanced biophysical methods now impacts almost every dimension of neuroscience research. By leveraging interactions between quantitative molecular & cellular biophysicts with neuroscientists focused on neurological, neurodevelopmental and neuropsychiatric diseases and those working on model systems, this unique training program equips students with the sophisticated skill sets needed among scientific leaders in neuroscience research.