Pre-doctoral Research Training in Human Genetic Epidemiology

描述（由申请人提供）：超出所提供的空间。这份重新修订的博士前培训拨款申请，是根据NIH PA-02-109提交的，要求支持在“跨文化”跨学科环境中培养未来的遗传流行病学家，通过将生物统计学和计算科学（遗传流行病学，生物统计学，统计遗传学和生物信息学）与生物科学（人类遗传学，分子生物学和基因组学）结合起来，使用非常成功和有效的实践方法。我们相对较新的博士预科课程“定量人类和统计遗传学”融合了传统和非传统的方法。该计划的主要目标是：(1)培训遗传流行病学家和统计遗传学家分子方法和分子数据分析技术；(2)培训人类遗传学家统计遗传学方法和方法，使他们能够有效地分析他们生成的数据。我们相信，这个博士预科项目将有效地减少文化冲击，这种文化冲击经常阻碍遗传流行病学家充分参与跨学科研究。这项培训经费将用于支持这个新开发的项目，该项目将面向本科专业为统计科学或生物科学且在其他方面有一定熟练程度的研究生。我们要求为第一年的4个名额和此后的6个名额提供资金。我们的建议是通过混合和整合精心选择的教学培训，更加强调在华盛顿大学非常成功的直接实践学习形式，来迎接挑战。该培训计划的一大优势是，整个DBBS的庞大的既定资源和丰富的跨学科培训环境，以及另一个硕士学位培训计划（GEMS），也可以为该计划的所有博士预科学生提供。我们希望，通过让我们的学生充分接触到成熟的DBBS项目和资源的广度和深度，我们确保我们的学生将以一种非常自然的方式完全融入生物医学科学，从而确保有效的“跨文化”培训。我们相信，我们的培训计划非常符合PA的精神，渴望培养未来的遗传流行病学家，以满足当前市场对合作生物医学研究的需求。

Description (provided by applicant): EXCEED THE SPACE PROVIDED. This re-revised pre-doctoral training grant application, submitted in response to NIH PA-02-109, requests support to train future Genetic Epidemiologists in a "cross-culture" interdisciplinary environment by integrating biostatistical and computational sciences (genetic epidemiology, biostatistics, statistical genetics, and bioinformatics) with biological sciences (human genetics, molecular biology, and genomics) using a highly successful and effective hands-on approach. Our relatively new pre-doctoral program in "Quantitative Human and Statistical Genetics" blends traditional and non-traditional approaches. The primary objectives of this program are: (1) To train Genetic Epidemiologists and Statistical Geneticists in molecular methods and molecular data analysis techniques, and (2) To train Human Geneticists in statistical genetics approaches and methods so that they can analyze competently the data they generate. We believe that this pre-doctoral program will effectively minimize the culture shock that often inhibits genetic epidemiologists from participating fully in interdisciplinary research. Funding of this training grant will support this newly developed program which will target graduate students whose undergraduate major was in either statistical sciences or biological sciences with some degree of proficiency in the other. We are requesting funds for 4 slots in the first year and 6 thereafter. Our proposal rises to the challenge by blending and integrating carefully chosen didactic training with greater emphasis on a direct hands-on learning format found to be immensely successful at Washington University. One of the great strengths of this training program is that the vast established resources and rich interdisciplinary training environment of the entire DBBS, as well as that of another masters degree training program (GEMS), are also available to all pre-doctoral students in this program. It is our hope that, by exposing our students to the full breadth and depth of the mature DBBS programs and resources, we are ensuring that our students will be fully integrated with the biomedical sciences in a very natural manner thus also ensuring effective "cross-culture" training. We believe that our training program is very much in the spirit of the PA, aspiring to produce future genetic epidemiologists in much demand in the current market place for pursuing collaborative biomedical research.