UNDERSTANDING THE ROLE OF ALTERNATIVE SPLICING IN THE TNFAIP3 SLE-RISK ALLELES

这个子项目是利用资源的许多研究子项目之一。 由NIH/NCRR资助的中心拨款提供。对子项目的主要支持 子项目的首席调查员可能是由其他来源提供的， 包括美国国立卫生研究院的其他来源。为子项目列出的总成本可能 表示该子项目使用的中心基础设施的估计数量， 不是由NCRR赠款提供给次级项目或次级项目工作人员的直接资金。 最近发现，某些基因变异会增加发展成系统性红斑狼疮的风险。该项目将定义这些风险单倍型在静止和刺激条件下可能产生的任何替代剪接模式，并将确定这些替代转录本的相对丰度。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. It has recently been discovered that certain genetic variants confer increased risk of developing SLE. This project will define any alternate splicing patterns that may arise from these risk haplotypes, both at rest and under stimulated conditions, and will determine the relative abundance of these alternate transcripts.