Investigation of genetic variation in the alcohol metabolism genes and other key

描述（由申请人提供）：暴露于烟草和酒精是口腔癌易感性的主要风险因素。遗传易感性发挥作用，与酒精代谢有关的基因的变异，特别是人类4号染色体上的ADH基因簇，似乎有助于疾病。国际癌症研究机构（IARC）开发了一项多中心病例对照研究（IARC多中心口腔癌研究），研究了来自9个不同国家和3个主要种族的约1600例病例和1600例对照个体，以调查口腔风险因素，特别是暴露于人乳头瘤病毒（HPV）、烟草和酒精。本申请中描述的项目的目标是在口腔癌的特定背景下调查来自上呼吸消化道癌的单独的大基因组全关联研究的新发现。特别是，我们将调查IARC国际口腔癌研究中的30种遗传变异，并调查这些变异如何影响欧洲、亚洲和非洲人群的风险。 公共卫生相关性：虽然暴露于烟草和酒精是关键的风险因素，但遗传变异也被认为在口腔和咽部癌症的易感性中发挥作用。该项目的目标是在口腔和咽部癌症的特定背景下，调查来自上消化道癌症的单独全基因组关联研究的新发现。

DESCRIPTION (provided by applicant): Exposure to tobacco and alcohol are the major risk factors involved in oral cancer susceptibility. Genetic susceptibility plays a role, with variation in the genes involved in metabolism of alcohol, particularly the ADH gene cluster on human chromosome 4, appearing to contribute to disease. The International Agency for Research on Cancer (IARC) has developed a multicentre case-control study (The IARC multicenter oral cancer study) of approximately 1600 cases and 1600 control individuals from 9 different countries and three major ethnicities to investigate oral risk factors, notably exposure to human papillomavirus (HPV), tobacco and alcohol. The goal of the project described in this application is to investigate new findings from a separate large genome wide association study of upper aerodigestive tract cancer in the specific context context of oral cancers. In particular we will investigate 30 genetic variants in the IARC international oral cancer study and investigate how these affect risk in European, Asian and African populations. Public Health Relevance: While exposure to tobacco and alcohol the key risk factors, genetic variation is also thought to play a role in susceptibility to cancers of the oral cavity and pharynx. The goal of this project is to investigate new findings from a separate genome wide association study of upper-areodigestive tract cancer in the specific context of cancers of the oral cavity and pharynx.