Genetic variants in nicotine addiction and alcohol metabolism genes, oral cancer risk and the propensity to smoke and drink alcohol: a replication study in India.
Genetic variants in nicotine addiction and alcohol metabolism genes, oral cancer risk and the propensity to smoke and drink alcohol: a replication study in India.
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DOI：
10.1371/journal.pone.0088240
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发表时间：
2014
期刊：
影响因子：
3.7
通讯作者：
McKay JD
中科院分区：
文献类型：
--
作者：
Anantharaman D;Chabrier A;Gaborieau V;Franceschi S;Herrero R;Rajkumar T;Samant T;Mahimkar MB;Brennan P;McKay JD
烟碱型乙酰胆碱受体和酒精代谢基因的遗传变异分别与吸烟和饮酒的倾向有关，也与头颈癌的遗传易感性有关。在印度，除了吸烟和饮酒外，咀嚼烟草也是口腔癌的一个重要风险因素。目前尚不清楚在这种不同的病因背景下，这些基因变异是否会影响倾向性或口腔癌易感性。我们检查了在印度进行的两项病例对照研究中的639例口腔和咽癌病例和791例对照。我们研究了六个已知影响尼古丁成瘾或酒精代谢的变异，包括rs16969968(CHRNA5)、rs578776(CHRNA3)、rs1229984(ADH1B)、rs698(ADH1C)、rs1573496(ADH7)和rs4767364(ALDH2)。Chrn变异与每天咀嚼烟草的次数有关，包括那些咀嚼烟草但从不吸烟的人(分别为rs16969968和rs578776的P = 0.003，P = 0.01)。与非携带者相比，变异等位基因的存在导致咀嚼频率大约13%的差异。未发现rs16969968与口腔癌风险相关(OR = 1.01，95%CI = 0.83~1.22)，rs578776与口腔癌风险降低16%(OR = 0.84，95%CI = 0.72~0.98)略有关联。在这一人群中，几乎没有证据表明编码酒精代谢的基因多态与口腔癌之间存在关联。Rs16969968与咀嚼次数之间的关联表明，该基因变异对吸烟倾向的影响延伸到无烟烟草的使用。
Genetic variants in nicotinic acetylcholine receptor and alcohol metabolism genes have been associated with propensity to smoke tobacco and drink alcohol, respectively, and also implicated in genetic susceptibility to head and neck cancer. In addition to smoking and alcohol, tobacco chewing is an important oral cancer risk factor in India. It is not known if these genetic variants influence propensity or oral cancer susceptibility in the context of this distinct etiology. We examined 639 oral and pharyngeal cancer cases and 791 controls from two case-control studies conducted in India. We investigated six variants known to influence nicotine addiction or alcohol metabolism, including rs16969968 (CHRNA5), rs578776 (CHRNA3), rs1229984 (ADH1B), rs698 (ADH1C), rs1573496 (ADH7), and rs4767364 (ALDH2). The CHRN variants were associated with the number of chewing events per day, including in those who chewed tobacco but never smoked (P = 0.003, P = 0.01 for rs16969968 and rs578776 respectively). Presence of the variant allele contributed to approximately 13% difference in chewing frequency compared to non-carriers. While no association was observed between rs16969968 and oral cancer risk (OR = 1.01, 95% CI = 0.83– 1.22), rs578776 was modestly associated with a 16% decreased risk of oral cancer (OR = 0.84, 95% CI = 0.72– 0.98). There was little evidence for association between polymorphisms in genes encoding alcohol metabolism and oral cancer in this population. The association between rs16969968 and number of chewing events implies that the effect on smoking propensity conferred by this gene variant extends to the use of smokeless tobacco.
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影响因子：
6.4
作者：
Gajalakshmi, V;Hung, RJ;Boffetta, P
通讯作者：
Boffetta, P
影响因子：
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Balaram, P;Sridhar, H;Franceschi, S
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