Iodinated disinfection byproducts from iodine tablets and chloramine disinfe--OLD

描述（由申请人提供）：最近在美国饮用水处理厂使用氯胺检测到碘化消毒副产物（DBP），氯胺是一种氯的消毒剂替代品，引入氯胺是为了最大限度地减少四种受管制的氯溴三卤甲烷（THM）的形成，THM是潜在的人类致癌物。饮用水中的碘化三卤甲烷和其他消毒副产物比氯溴对应物对哺乳动物细胞更具遗传毒性和细胞毒性。因此，发现和尽量减少这些物质对保护公众健康至关重要。我们的研究旨在验证，在我们的实验室，检测这些化合物的灵敏和特异性的分析方法，以测量它们在氯化饮用沃茨中的出现，以确定它们在用紧急消毒碘片处理的天然沃茨中形成的可能性，以测量颗粒活性炭过滤器从水中去除碘化DBPs的能力，并确定与使用碘片作为饮用水消毒的使用点策略相关的潜在人类健康风险。 公共卫生相关性：由于它们对人类有明显的毒性，碘化消毒副产物对（1）长期依赖碘片或碘化树脂过滤器进行饮用水消毒的军队或和平队志愿者和（2）具有饮用水处理厂的沿海社区构成潜在的公共卫生风险，所述饮用水处理厂用氯胺消毒处理其高碘化物水源水，所述氯胺消毒将碘化物转化为碘。我们的试点研究旨在测量在这两种情况下碘化消毒副产物的发生率，并确定与这些暴露相关的潜在人类健康风险。

DESCRIPTION (provided by applicant): Iodinated disinfection byproducts (DBPs) have recently been detected in US drinking water treatment plants using chloramine, a disinfectant replacement for chlorine that was introduced in order to minimize the formation of the four regulated chloro-bromo trihalomethanes (THMs), which are potential human carcinogens. The iodinated THMs and other DBPs in drinking water are more genotoxic and cytotoxic to mammalian cells than the chloro-bromo counterparts. Therefore, their detection and minimization is crucial to protect public health. Our study aims to validate, in our laboratory, sensitive and specific analytical methods for detection of these compounds, to measure their occurrence in chloraminated drinking waters, to determine the potential for their formation in natural waters treated with emergency disinfection iodine tablets, to measure the ability of granular activated carbon filters to remove iodinated DBPs from water, and to identify the potential human health risk associated with use of iodine tablets as a point-of- use strategy for disinfection of drinking water. PUBLIC HEALTH RELEVANCE: Due to their apparent toxicity to humans, the iodinated disinfection byproducts pose a potential public health risk to (1) military troops or Peace Corps volunteers that rely on iodine tablets or iodinated resin filters for drinking water disinfection for long periods of time and (2) coastal communities with drinking water treatment plants that treat their high iodide source water with chloramine disinfection which transforms the iodide to iodine. Our pilot study aims to measure the occurrence of iodinated DBPs in both cases and to identify the potential human health risk associated with these exposures.