Protective T cell responses to Chlamydial Infection

盆腔炎性疾病（PID）定义为子宫内膜、输卵管及其邻近组织的感染， 这是由微生物从下生殖道Ascension到上生殖道引起的。 最令人信服的与PID相关的微生物是沙眼衣原体，我们的建议将 为发现抗原特异性细胞介导的免疫反应提供了令人兴奋的机会， 最强相关的保护对C。沙眼感染以及抗原的阐明 特异性免疫应答与C.下生殖道沙眼感染的 将从急性PID队列（项目1）中招募200名入组本纵向研究的女性 以及来自宫颈内感染C.沙眼（项目4）。 完成我们的调查将允许： 1.更好地理解与CD4 T细胞抗原特异性反应密切相关的CD4 T细胞抗原特异性反应， 保护C。入组时的沙眼感染。 2.更好地阐明了CD4 T细胞抗原特异性应答，这些应答与 保护免受C事件的影响。沙眼感染 3.鉴定新的衣原体特异性T细胞应答，其与免疫应答最密切相关。 降低了C Ascension的可能性。沙眼从下到上生殖道。

Pelvic inflammatory disease (PID) is defined as an infection of the endometrium, fallopian tubes, and adjacent structures that is caused by the ascension of microorganisms from the lower to upper genital tract The microorganism most convincingly associated with PID is Chlamydia trachomatis, and our proposal would provide the exciting opportinity for a discovery of the antigen-specific cell mediated immune resposes that are most strongly associated with protection against C. trachomatis infection as well as the elucidation of the antigen specifc immune responses correlated with containment of C. trachomatis infection to the lower genital tract. The 200 women enrolled into this longitudinal investigation will be recruited from an acute PID cohort (Project 1) and from a cohort of women who are at high risk for endocervical infection with C. trachomatis (Project 4). Completion of our investigation will allow: 1. Better understanding of the CD4 T cell antigen-specific responses that are most strongly associated with protection from C. trachomatis infection at enrollment. 2. Better elucidation of the CD4 T cell antigen-specific responses that are most strongly correlated with protection from incident C. trachomatis infection. 3. Identification of novel chlamydia-specific T cell responses that are most strongly associated with the decreased likelihood of ascension of C. trachomatis from the lower to upper genital tract.