Reactivity and Regulation in the Intergenerational Transmission of PTSD

该指导临床科学家发展奖（K 08）的目的是使候选人成为一名独立的研究人员，对母亲PTSD对养育子女，儿童反应和调节的影响进行综合研究，以及创伤性应激的代际传递。该奖项的长期目标是准备候选人告知和设计干预方案，减轻母亲创伤后应激障碍对儿童的负面影响，并中断创伤后应激障碍的代际传播。为了实现这些目标，候选人将完成职业发展计划，重点是促进管理和解释与反应和调节有关的心理生物学功能的多种措施的能力;创伤应激领域的方法，特别强调理解母亲创伤后应激障碍对儿童结果的影响以及创伤后应激障碍代际传播的潜在机制;以及纵向数据收集和统计分析技术。培训将通过课程、辅导和专家咨询以及具体的研究项目来完成。该研究开发计划的重点是测试一个特定的模型的影响，母亲创伤后应激障碍的父母，儿童的反应，自我调节的发展，作为潜在的中介在代际传递的创伤性应激反应。研究计划包括两项研究：1）对母亲PTSD、父母养育和婴儿第一年的反应和调节能力之间的关联进行前瞻性检查; 2）对创伤前调节能力在创伤暴露后PTSD发展中的作用进行前瞻性分析。通过该奖项获得的培训将准备候选人提交R 01申请，用于对母亲PTSD对儿童结局的作用和潜在的潜在影响机制进行纵向研究。相关性：这项工作将有助于为干预工作提供信息，以减轻母亲创伤后应激障碍对儿童的负面影响，防止创伤性应激的代际传播，明确创伤后应激障碍病因学中风险和复原力的发展模型，并识别和治疗有风险的创伤儿童。这项工作也将有更普遍的影响，了解发展的自我调节能力，在多个系统中的典型和非典型人群和干预人群的风险监管困难。

DESCRIPTION (provided by applicant): Project Summary: The purpose of this Mentored Clinical Scientist Development Award (K08) is to enable the candidate to become an independent investigator conducting integrative research on the impact of maternal PTSD on parenting, child reactivity and regulation, and the intergenerational transmission of traumatic stress. The long-term goal of this award is to prepare the candidate to inform and design intervention programs that mitigate the negative impact of maternal PTSD on children and interrupt the integenerational transmission of PTSD. To accomplish these goals, the candidate will complete a career development plan focused on promoting competence in the administration and interpretation of multiple measures of psychobiological functioning relevant to reactivity and regulation; methodology in the field of traumatic stress, with a particular emphasis on understanding the effects of maternal PTSD on child outcome and potential mechanisms involved in the intergenerational transmission of PTSD; and longitudinal data collection and statistical analysis techniques. Training will be accomplished via coursework, tutorials and consultation with experts, and specific research projects. The research development plan is focused on testing a specific model of the impact of maternal PTSD on parenting, child reactivity, and the development of self-regulation as potential mediators in the intergenerational transmission of traumatic stress. The research program consists of two studies: 1) a prospective examination of associations among maternal PTSD, parenting, and infant reactivity and regulatory abilities in the first year; and 2) a prospective analysis of the role of pre- trauma regulation abilities in the development of PTSD following trauma exposure. Training obtained via this award will prepare the candidate to submit an R01 application for a longitudinal study of the role of maternal PTSD on child outcome and potential underlying mechanisms of effects. Relevance: This work will help inform intervention efforts to mitigate the negative impact of maternal PTSD on children, prevent the intergenerational transmission of traumatic stress, specify developmental models of risk and resilience in the etiology of PTSD, and identify and treat at-risk traumatized children. This work will also have more general implications for understanding the development of self-regulatory abilities across multiple systems in typical and atypical populations and for intervening with populations at risk for regulatory difficulties.