Tools for Economic Analysis of Patient Management Interventions in Heart Failure

描述（由申请人提供）：为了最大限度地提高社会卫生保健资金的价值，各级决策者需要工具来系统地比较与卫生保健干预措施相关的成本和收益。评价以患者为中心的干预措施的成本效益特别具有挑战性，特别是在对这些干预措施进行准确和全面的成本评估以及预测其对健康和生活质量的长期影响方面。拟议项目TEAM-HF的目标是：心力衰竭患者管理干预措施的经济分析工具，旨在开发工具，以促进心力衰竭医疗保健干预措施的高质量经济评估，特别是涉及以患者为中心的教育或行为矫正元素的评估。该应用程序概述了4个项目，将（1）帮助标准成本计算方法的应用;（2）促进正式的成本效益分析的进行;（3）展示疾病模拟建模在确定更高的计划效率和高价值研究机会方面的力量。在第一个项目中，将设计一个由一系列电子表格组成的成本计算工具，以系统地估计与实施和维持以患者为中心的干预措施相关的成本。这个工具可以应用于针对任何医疗条件的计划。第二个项目涉及开发一个用户友好的概率疾病模拟模型，以评估心力衰竭的短期和长期成本和健康结果。该工具可应用于以患者为中心或向心力衰竭患者提供的其他医疗干预。该模型将使用最近完成的一项NIH赞助的大型心力衰竭试验（HF-ACTION）的丰富纵向数据集开发。成本计算工具和疾病模拟模型都将使用Microsoft Excel开发，以便向潜在用户广泛传播。第三和第四个项目将使用疾病模拟模型来逆向工程以患者为中心的干预措施，这些干预措施最有可能具有成本效益，并进行信息价值分析，以优先考虑未来的研究工作。 公共卫生相关性：美国越来越需要限制卫生支出的增长。经济评价提供了一种区分高价值和低价值卫生保健干预措施的工具。TEAM-HF项目将为临床医生和研究人员提供用户友好的工具，以促进对以患者为中心的干预措施进行高质量的经济评估。

DESCRIPTION (provided by applicant): To maximize the value of society's health care dollars, decision makers at all levels need tools to systematically compare costs and benefits associated with health care interventions. Evaluating the cost-effectiveness of patient-focused interventions is particularly challenging, especially in developing accurate and comprehensive cost assessments of such interventions and projecting their long-term impact on health and quality of life. The objective of the proposed project, TEAM-HF: Tools for Economic Analysis of Patient Management Interventions in Heart Failure, is to develop tools to facilitate the conduct of high-quality economic evaluations of health care interventions in heart failure, particularly those that involve patient-focused educational or behavioral modification elements. This application outlines 4 projects that will (1) aid in the application of standard costing methods; (2) facilitate the conduct of formal cost-effectiveness analyses; and (3) demonstrate the power of disease simulation modeling in identifying opportunities for greater program efficiency and high-value research. In the first project, a costing tool composed of a series of spreadsheets will be designed to systematically estimate costs associated with implementing and maintaining a patient-focused intervention. This tool could be applied to programs targeting any medical condition. The second project involves the development of a user-friendly, probabilistic, disease simulation model to evaluate short- and long-term costs and health outcomes in heart failure. This tool could be applied to patient-focused or other medical interventions provided to patients with heart failure. The model will be developed using a rich set of longitudinal data from a recently completed, large NIH-sponsored trial in heart failure (HF-ACTION). Both the costing tool and the disease simulation model will be developed using Microsoft Excel to allow for wide dissemination to potential users. The third and fourth projects will use the disease simulation model to reverse engineer patient-centered interventions that are most likely to be cost-effective and to conduct value-of-information analyses to prioritize future research efforts. PUBLIC HEALTH RELEVANCE: There is an increasing need to limit growth in health spending in the United States. Economic evaluation provides a tool to discriminate between higher-value and lower-value health care interventions. The TEAM-HF projects will provide clinicians and researchers with user-friendly tools to facilitate the conduct of high-quality economic evaluations of patient-focused interventions.