p53 Family in Gastric Cancer Development

描述（由申请人提供）：胃癌是世界上第四大最常见的癌症，也是第二大最常见的癌症死亡原因。这种恶性肿瘤被认为是难以治疗的，手术是目前治疗的主要手段，但却有很高的发病率和死亡率。为了更好地治疗和预防这种疾病，了解影响其发展的因素是很重要的。P53肿瘤抑制因子是在胃肿瘤预防中起重要作用的细胞因子之一。尽管p53蛋白已经被很好地表征，但对p53家族的其他成员p73和p63知之甚少。越来越多的证据表明，p73和p63显著影响p53的活性和功能，并协同p53调控肿瘤发生。我们的数据表明p73在胃上皮细胞与幽门螺杆菌的相互作用中起重要作用，幽门螺杆菌是一种革兰氏阴性细菌病原体，是胃癌发展的重要危险因素。我们的目标是通过小鼠模型和其他体外和体内方法来描述p53蛋白家族在胃肿瘤发展中的作用。这些综合研究可能为开发新的预后和治疗靶点提供新的途径。

DESCRIPTION (provided by applicant): Gastric cancer is the fourth most common form of incident cancer and the second most common cause of cancer death in the world. This malignancy is considered to be poorly treatable, and the surgery that is the mainstay of current treatment carries significant morbidity and mortality. To better treat and prevent this disease, it is important to understand factors that affect its development. p53 tumor suppressor is among the cellular factors that play an important role in the prevention of gastric tumors. Although the p53 protein has been relatively well characterized, less is known about other members of the p53 family, p73 and p63. Accumulating evidence suggest that p73 and p63 significantly affect the p53 activity and function in concert with p53 in regulation of tumorigenesis. Our data suggest that p73 plays an important role in the interaction of gastric epithelial cells with H. pylori, a Gram-negative bacterial pathogen that is a prominent risk factor for the development of gastric cancer. We aim to delineate the role of the p53 protein family in the development of gastric tumor using mouse models and other in vitro and in vivo approaches. These comprehensive studies may provide new avenues for the development of novel prognostic and therapeutic targets. PUBLIC HEALTH RELEVANCE: Gastric cancer is the second most common cause of cancer death in the world. Despite recent advances in treatment of this disease, gastric cancer remains to be a serious health problem. Our research analysis may provide valuable information on the mechanisms of development of this disease and its potential treatment.