Translation of Quantitative Imaging in Osteoarthritis

描述（由申请人提供）：这个题为“骨关节炎定量成像的转化”（TOQIO）的提案的总体目标是整合尖端的定量成像技术，将图像衍生指标与关节运动学，动力学，患者功能联系起来，并将发现的联系转化为肌肉骨骼临床，从而影响患者管理和结果。为了实现这些目标，我们有一个包括骨科医生、风湿病学家、成像科学家、生物工程师、物理治疗师、流行病学家和生物学家在内的联合团队。该团队建立在研究者之间跨学科合作的坚实基础之上，重点是转化研究，并得到了众多研究者个人和项目资助的支持，这些资助在研究者和机构之间建立了这些合作研究伙伴关系。TOQIO的主要目标是：(i)提供基础设施并发展一个跨学科团队，将有前途的新成像方法和非侵入性生物标志物从原理证明转化为人类受试者的研究/试验，并最终转化为广泛可用的临床工具，直接影响骨关节炎患者的护理和管理；（ii）开发与功能相关的定量成像测量和生物力学之间的模型和关系，不仅用于监测和诊断骨关节炎，还用于评估临床试验中的药物或手术治疗和受试者选择；（iii）开发一个教育项目，让开发与骨关节炎研究相关的新技术的成像专家教授基础和临床科学家如何使用这些方法来加强他们的研究，并将成像信息转化为骨关节炎的诊断和临床管理，同时利用TOQIO的核心主题开发新的试点和可行性项目。TOQIO包括一个行政核心，四个研究项目，以及两个研究和科学核心：成像和数据分析以及人类性能和功能测试。此外，将有来自加州大学旧金山分校和加州大学戴维斯分校的参与者，以及一个优秀的外部咨询委员会，其中包括来自社区成员的意见。

DESCRIPTION (provided by applicant): The overall objective of this proposal entitled " Translation of Quantitative Imaging in Osteoarthritis" (TOQIO) is to integrate cutting edge quantitative imaging technologies, link the image derived metrics to joint kinematics, kinetics, patient function, and translate the linkages found to the musculoskeletal clinic, thus affecting patient management and outcome. In order to accomplish these objectives we have a combined team that includes orthopedic surgeons, rheumatologists, imaging scientists, bioengineers, physical therapists, epidemiologists, and biologists. This team is built upon the strong foundation of interdisciplinary collaborations between the investigators, with a focus on translational research, and is supported by numerous individual investigator and programmatic grants that have established these collaborative research partnerships between the investigators and the institutions. The major goals of TOQIO are to (i) provide the infra-structure and develop an inter-disciplinary team to translate promising new imaging methodologies and non-invasive biomarkers from proof of principle to studies/trials in human subjects, and ultimately into widely available clinical tools that directly impact patient care and management of osteoarthritis; (ii) to develop models and relationships between the quantitative imaging measures and biomechanics that are relevant to function, not only for monitoring and diagnosing osteoarthritis, but also for assessing pharmaceutical or surgical therapies and subject selection in clinical trials; and (iii) to develop an educational program in which imaging specialists that develop the novel techniques relevant to osteoarthritis research teach basic and clinical scientists how to use such approaches in enhancing their research and translate the imaging information to the diagnosis and clinical management of osteoarthritis, as well as develop new pilot and feasibility projects utilizing the themes central to TOQIO. TOQIO consists of an administrative core, four research projects, and two research and scientific cores: Imaging and Data Analysis and Human performance and Functional Testing. In addition, there will be participants from UCSF and UC Davis and an excellent External Advisory Committee that includes lay input from a community member. PUBLIC HEALTH RELEVANCE: Osteoarthritis (OA) is the second most common cause of permanent disability among subjects over the age of fifty. This proposal will develop methods of imaging that can be used for more effective diagnosis and monitoring of OA.