The Biology of Integrated Nuclear and Extranuclear Steroid Signaling

描述（由申请人提供）：传统上认为类固醇介导的过程受核受体转录活性变化的调节。然而，临床线索表明，类固醇也信号独立于转录（非基因组）。例如，肾上腺皮质功能不全患者的糖皮质激素治疗导致症状缓解和ACTH在几分钟内降低-太快而不涉及转录和随后蛋白质表达的变化。因此，研究表明，类固醇可以激活快速的，核外的，不依赖于转录的信号。虽然这些作用的重要性最初受到了健康的怀疑，但类固醇的非基因组作用现在被接受参与调节许多重要的生物过程，包括增殖，凋亡，血管生成，神经元信号传导和生殖细胞发育。此外，核外和核内类固醇受体信号传导已显示协同作用，由此核外类固醇信号增强核内类固醇介导的转录。最后，对类固醇触发的、转录非依赖性途径的研究揭示了目前被靶向以抑制激素依赖性肿瘤过程的新的信号传导机制。 这个FASEB和内分泌学会主办的会议的目的是汇集研究人员研究转录独立和依赖类固醇信号，努力促进串扰和合作，以及进一步统一类固醇信号领域。本次会议的三个目的是：1）回顾核外和转录类固醇信号领域令人兴奋的新发现; 2）为年轻的研究人员提供一个场所，展示他们的工作，并与类固醇信号领域的领导者互动; 3）讨论类固醇信号研究的重要转化意义。 公共卫生相关性：类固醇调节许多重要的生物过程，涉及生殖，心血管健康，肾功能，肿瘤生长和神经功能。本次会议提供了一个场地，专家，新的调查人员，和学员在类固醇信号，以满足和讨论新的和令人兴奋的发现在该领域。会议将重点关注基础科学发现与新的治疗方法，涉及改变类固醇信号治疗疾病，如癌症或不孕症。

DESCRIPTION (provided by applicant): Steroid-mediated processes have traditionally been thought to be regulated by changes in nuclear receptor transcriptional activity. However, clinical clues have suggested that steroids also signal independent of transcription (non-genomic). For example, glucocorticoid treatment of patients with adrenal insufficiency results in symptomatic relief and a lowering of ACTH within minutes - much too rapidly to involve changes in transcription and subsequent protein expression. Accordingly, studies have now demonstrated that steroids can activate rapid, extra-nuclear, transcription-independent signals. While the importance of these effects was first met with healthy skepticism, non-genomic actions of steroids are now accepted to participate in regulating many important biological processes, including proliferation, apoptosis, angiogenesis, neuronal signaling, and germ cell development. In addition, extra- and intra-nuclear steroid receptor signaling have been shown to work in synergy whereby extra-nuclear steroid signals enhance intra-nuclear steroid- mediated transcription. Finally, the study of steroid-triggered, transcription-independent, pathways has revealed novel signaling mechanisms that are currently being targeted to suppress hormone- dependent neo-plastic processes. The purpose of this FASEB- and Endocrine Society-sponsored conference is to bring together investigators studying both transcription-independent and -dependent steroid signaling in an effort to foster cross talk and collaboration, as well as to further unify the field of steroid signaling. The three aims of this conference are: 1) To review exciting new discoveries in the fields of both extra-nuclear and transcriptional steroid signaling; 2) To provide a venue for young investigators to present their work and interact with established leaders in the field of steroid signaling; and 3) Discuss the important translational implications of steroid signaling research. PUBLIC HEALTH RELEVANCE: Steroids regulate many important biological processes that are involved in reproduction, cardiovascular health, kidney function, tumor growth, and neurological functions. This conference provides a venue for experts, new investigators, and trainees in steroid signaling to meet and discuss the new and exciting discoveries in the field. The conference will focus on relating basic science discoveries with new therapeutic approaches that involve altering steroid signaling to treat diseases such as cancer or infertility.