Aerobic and Resistance Exercise for Cancer-Related Fatigue During Radiation

描述（由申请人提供）：概述：Karen Mustian博士，她是一位运动心理学家，正在申请一个指导职业发展奖，以扩大她的研究技能，并成为一名独立的癌症控制调查员。她的目标是促进对运动干预的理解，以减少癌症治疗的副作用，特别是癌症相关性疲劳（CRF）;患者中最常见的副作用。拟议的项目在理论上是由CRF研究和去/调节理论指导的，该理论认为减少身体活动会导致肌肉质量和力量的损失，而阻力运动可以改善两者。职业发展计划：Mustian博士以前在运动心理学，行为医学和癌症控制方面的研究和培训提供了坚实的基础，这将通过研究技能，癌症控制，综合系统生物学和生理学以及健康技术的具体可测量学习的教育计划来加强。她的主要导师，加里莫罗博士，30年来一直是癌症控制研究和培训的领导者。他将在癌症和副作用管理以及随机临床试验设计和分析方面提供专业知识。Mustian博士的共同导师也有培训研究人员的特殊经验。Alice Pentland，医学博士将贡献癌症生物学和跨学科研究方面的专业知识，以创造用于定量评估的健康技术。Anne McTiernan医学博士博士将贡献运动和癌症方面的专业知识。顾问委员会成员还将为Mustian博士的职业发展贡献他们独特的专业知识。研究计划：拟议的研究项目是一项随机临床试验，以扩大可行性研究的积极结果，并检查114名接受放射治疗的乳腺癌患者的家庭步行和渐进式阻力运动计划对CRF的影响。次要研究目标是提供关于潜在CRF病因学因素的试点信息，包括骨骼肌质量损失、力量变化和与蛋白酶体泛素途径相关的炎症反应失调，以及使用体动记录仪运动数据作为CRF的独立标志物。这些结果将有助于阐明运动对CRF的公共健康影响，有助于为CRF定制运动干预措施，为未来的R 01研究提供有关CRF潜在病因和独立标志物的试点数据，并使Mustian博士成功过渡到癌症控制科学的独立研究者和领导者。

DESCRIPTION (provided by applicant): Overview: Karen Mustian, Ph.D., an exercise psychologist, is applying for a mentored career development award to expand her research skills and become an independent investigator in cancer control. Her goal is to contribute to the understanding of exercise interventions for reducing the side effects of cancer treatments, specifically, cancer-related fatigue (CRF); the most prevalent side effect in patients. The proposed project is theoretically guided by CRF research and de/conditioning theory positing reduced physical activity results in loss of muscle mass and strength, and resistance exercise improves both. Career Development Plan: Dr. Mustian's previous research and training in exercise psychology, behavioral medicine, and cancer control provide a strong foundation that will be enhanced by the educational plan of specific measurable learning in research skills, cancer control, integrative systems biology and physiology, and health technology. Her primary mentor, Gary Morrow, Ph.D., has been a leader in cancer control research, and training for 30 years. He will contribute expertise in cancer and side effect management and in randomized clinical trial design and analyses. Dr. Mustian's co-mentors also have exceptional experience training researchers. Alice Pentland, M.D. will contribute expertise in cancer biology, and interdisciplinary research to create health technology for quantitative assessment. Anne McTiernan, M.D., Ph.D. will contribute expertise in exercise and cancer. Advisory board members will also contribute their unique expertise to Dr. Mustian's career development. Research Plan: The proposed research project is a randomized clinical trial to expand the positive findings of a feasibility study and examine the influence of a home-based walking and progressive resistance exercise program on CRF in 114 breast cancer patients undergoing radiation. Secondary research goals are to provide pilot information on potential CRF etiological factors, including skeletal muscle mass loss, strength changes, and dysregulation of inflammatory responses associated with the proteasome ubiquitin pathway, and on the use of actigraphy motion data as an independent marker of CRF. These results will help elucidate the public health impact of exercise on CRF, assist in tailoring exercise interventions for CRF, provide pilot data on potential etiological factors and independent markers of CRF for a future R01 study, and position Dr. Mustian to successfully transition to an independent investigator and leader in cancer control science.