Electronics Consoles for Biomolecular NMR

描述（由申请人提供）：总体目标是为美国国立卫生研究院资助的乔治亚州和邻近地区的生物医学研究人员提供生物分子核磁共振光谱的前沿技术和能力。生物分子和生物分子系统的进步、全面的研究需要原子水平的结构和运动特征的分辨率。这是现代生物分子核磁共振方法的强项。该提案是替换老化的（12年），过时的和越来越不可靠的电子控制台上的600和800兆赫核磁共振光谱仪的主力车，包括核心，大量使用核磁共振仪器在格鲁吉亚的研究人员解决结构生物学的研究问题。仪器将由杰出的专家人员维护和管理，并安置在乔治亚大学的特殊设施中。一个经验丰富的咨询小组将继续指导和丰富设施的运作，以确保设施的持续成功和生物医学研究人员的使用。新仪器的新功能和改进的性能将被用于解决各种重要的生物医学研究课题。这些包括蛋白质化学的一般问题，结构生物学的方法发展，糖蛋白和糖生物学，翻译后修饰，钙信号，膜-蛋白质相互作用，医学成像的造影剂，内毒素-受体相互作用，细胞通讯，RNA结构和RNA-蛋白质相互作用。这些研究结果将对人类健康问题，如败血症、病毒感染、癌症、免疫学、甲状腺疾病、囊性纤维化等具有重要意义。新仪器还将丰富我们的教育计划和下一代生物医学研究人员的教育经验，它将增强我们的核磁共振设施资源，提高设施的使用和效率，并将成为生物分子核磁共振和生物医学研究持续、长期支持的组成部分。

DESCRIPTION (provided by applicant): The overall goal is to provide leading edge technologies and capabilities in biomolecular NMR spectroscopy to investigators in Georgia and neighboring areas for NIH-sponsored biomedical research. Progressive, comprehensive studies of biomolecules and biomolecular systems require atomic level resolution of structural and motional features. These are a forte of modern biomolecular NMR methodologies. The proposal is to replace aging (12 year old), outdated and increasingly unreliable electronics consoles on the workhorse 600 and 800 MHz NMR spectrometers that comprise core, heavily used NMR instrumentation for investigators in Georgia for addressing research questions in structural biology. The instrumentation will be maintained and administered by outstanding expert staff and housed in exceptional facilities at the University of Georgia. An experienced advisory team will continue to guide and enrich facility operations to ensure continued facility success and access for biomedical researchers. New capabilities and improved performance of the new instrumentation will be exploited to tackle a diverse collection of important biomedical research topics. These include general issues in protein chemistry, methods development for structural biology, glycoproteins and glycobiology, post-translational modification, calcium signaling, membrane-protein interactions, contrast agents for medical imaging, endotoxin-receptor interactions, cellular communication, RNA structure and RNA-protein interactions. The results of these investigations will be important to human health issues such as sepsis, viral infection, cancer, immunology, thyroid disease, cystic fibrosis and many others. The new instrumentation will also enrich our educational programs and the educational experiences of the next generation of biomedical researchers, it will enhance our NMR facility resources and improve facility use and efficiency, and will be integral to continued, long-term support for biomolecular NMR and biomedical research. PUBLIC HEALTH RELEVANCE: The biomedical research supported by the requested instrumentation is being used to address many issues of fundamental importance directly relevant to human health. These include bacterial and viral infections, breast cancer, thyroid disease, and many others. The expectation is that the knowledge gained from the studies will influence development of new therapies and treatments.