Small Animal PET/SPECT/CT Molecular Imaging

描述(申请人提供)：这项建议是为了获得最先进的小动物PET/CT分子成像仪的资金。本机构已承诺投入资源支持、开发和维护这一文书。它将提供小动物体内高分辨率的放射性核素分子成像，并使用计算机断层扫描(CT)进行精确的解剖关联。高分辨率正电子发射断层扫描(PET)提供了一种非侵入性的方法来可视化体内的分子事件。这对医学研究至关重要，因为它将使体内疾病机制的基础科学研究成为可能。整个大学和医学中心的肿瘤学家、心脏病专家和其他研究人员将能够在当代小动物模型中进行纵向的活体分子成像研究。通过在体内测试和开发新的放射性示踪剂，放射化学的基础科学也将大大受益。放射化学家可以有效地确定新型放射性示踪剂的体内生物分布、辐射剂量学和放射性示踪剂动力学。此外，先进的治疗方法也可以在活体小动物模型中进行测试和开发，使用可以监测治疗反应的早期分子事件的放射性示踪剂。各种各样的先进疗法可能既包括新的药物化合物，也包括新的策略，如基于细胞的疗法。除了有助于理解病理生理学的基本机制外，放射性示踪技术还证明了诊断和治疗应用的人体安全性。因此，新的放射性示踪剂、放射性示踪剂方法和治疗监测技术对活体人体研究具有很高的转换性。 公共卫生相关性：我们计划使用这种仪器来研究医学疾病发生的原因，测试检测疾病的新方法，并在新疗法用于人类之前测试它们。这可以极大地推动医学以及癌症、心脏病和其他多种人类疾病的治疗。研究活组织中的疾病对于了解疾病是如何发生的、测试新的非侵入性测试以及在人类使用之前测试新疗法的安全性和有效性至关重要。

DESCRIPTION (provided by applicant): This proposal is to obtain funding for a state-of-the-art small animal PET/CT molecular imaging instrument. Our institution has committed resources to support, develop and maintain this instrument. It will provide small animal high resolution in vivo radionuclide molecular imaging with precise anatomic correlation using computed tomography (CT). High-resolution positron emission tomography (PET) provides a non-invasive method to visualize molecular events in vivo. This is critical to medical science investigations because it will enable basic science studies of in vivo mechanisms of disease. Oncologists, cardiologists, and other investigators throughout the University and Medical Center will be able to perform longitudinal, in vivo molecular imaging studies in contemporary small animal models. The basic science of radiochemistry will also tremendously benefit through testing and development of novel radiotracers in vivo. Radio chemists can efficiently determine the in vivo biodistribution, radiation dosimetry, and radiotracer kinetics of novel radiotracers. Furthermore, advanced therapeutics can also be tested and developed in in vivo small animal models, using radiotracers which can monitor the early molecular events of a therapeutic response. A wide array of advanced therapeutics may include both novel drug compounds and novel strategies such as cell based therapies. In addition to contributing to understanding basic mechanisms of pathophsiology, radiotracer techniques have proven human safety for both diagnostic and therapeutic applications. Novel radiotracers, radiotracer methods, and therapeutic monitoring techniques are, therefore, highly translational to in vivo human studies. PUBLIC HEALTH RELEVANCE: We plan to use this instrument to study the reasons why medical diseases occur, to test new methods to detect disease, and to test new therapies before they are used in humans. This can greatly advance medical science and the treatment of cancer, heart disease, and a wide variety of other human diseases. Studying disease in live tissues is essential to understanding how diseases occur, testing new non-invasive tests, and testing safety and efficacy of new therapies before human use.