Core B - Sheep Core

“绵羊核心”的目标是提供一种机制， 由本计划项目赠款的所有项目共享，使具有成本效益的育种和动物 高标准的维护计划。这个核心的基本原理很简单。一 高素质的工作人员可以更有效地满足多个研究项目的需要， 比每个项目单独满足其需求更经济。这一点尤其重要，因为 这个核心的主要功能是产生已经通过暴露于 已知怀孕阶段的性腺类固醇。这需要丰富的经验和专业知识， 管理这个实验物种的生育、繁殖和产后早期护理。的具体目标 羊的核心如下。具体目标1。来进行一个繁殖计划， 在特定胎龄时用性腺类固醇进行产前处理和赋形剂处理的对照， 三个研究项目组成了这个项目资助。具体目标2。协调有效 和经济利用羊的三个相互关联的研究项目。具体目标3。提供一种 统一和高标准的动物维护和兽医护理。具体目标4。提供一种 建立绵羊生殖研究技术知识库，并培训人员正确处理 动物具体目标5.为了确定所需的实验动物的代谢状态， 满足三个项目的需求。通过实现这些目标，绵羊核心将大大提高 所有项目的生产力在计划项目补助金。

The objective of the Sheep Core is to provide a mechanism whereby the services of common personnel are shared by all projects of this Program Project Grant, enabling cost-effective breeding and animal maintenance programs of exceptionally high standards. The underlying rationale for this Core is simple. A staff of well-qualified individuals can meet the needs of multiple research projects more effectively and economically than if each project were to meet its needs separately. This is especially important given that a major function of this core will be to generate sheep that have been programmed prenatally by exposure to gonadal steroids at known stages of pregnancy. This requires extensive experience and expertise of managing fertility, breeding, and early postnatal care in this experimental species. The Specific Aims of the Sheep Core are as follows. Specific Aim 1. To operate a breeding program to generate sheep those are prenatally treated with gonadal steroids at specific fetal ages and vehicle-treated controls for use by the three research projects that make up this Program Project Grant. Specific Aim 2. To coordinate effective and economical usage of sheep by three interrelated research projects. Specific Aim 3. To provide a uniform and high standard of animal maintenance and veterinary care. Specific Aim 4. To provide a technical knowledge base for reproductive research in sheep and train personnel in proper handling of animals. Specific Aim 5. To determine the metabolic status of the experimental animals required for meeting the needs of all 3 projects. By achieving these aims, the Sheep Core will greatly enhance the productivity of all projects in the Program Project Grant.