SPORE in Gastrointestinal Cancer

此次申请胃肠道(胰腺癌)卓越研究专项计划将专注于转化性研究，解决对改善胰腺癌患者预后至关重要的基础和临床问题。具体地说，该计划中的研究项目旨在：1)开发和测试新的诊断试剂和分析方法，以提高我们在早期阶段发现胰腺癌的能力；2)为早期和晚期胰腺癌患者开发和测试新的治疗策略，包括免疫疗法、化疗和化学放射疗法；3)结合临床试验进行基础研究，从分子水平深入了解不同策略成功和失败的原因。拟议的孢子计划侧重于4个具有高潜在翻译影响的项目，有2个高度互动的核心将继续获取、存储和提供一套独特的组织样本、数据(临床、分子遗传学、生物学、病理学)、试剂和资源： 项目1：胰腺癌的免疫治疗 项目2：N-钙粘素抑制剂在胰腺癌治疗中的应用。 项目3：生物标志物(S)在胰腺癌诊断中的应用 项目4：端粒酶抑制剂治疗胰腺癌 核心1：管理 核心2：胰腺肿瘤孢子组织库 核心3：生物统计学

This application for a Specialized Program of Research Excellence in Gastrointestinal (Pancreatic Cancer) will focus on translational studies that address basic and clinical issues of importance to improving the outcome of patients with pancreatic cancer. Specifically, the research projects in this program seek to: 1) develop and test novel diagnostic reagents and assays that will improve our ability to detect pancreatic cancer in its early stages; 2) develop and test novel therapeutic strategies including immunotherapy, chemotherapy, and chemoradiation therapy for patients with early and advanced pancreatic cancer; 3) undertake basic research studies in conjunction with clinical trials that will provide insight at the molecular level into the reasons for success and failure of the different strategies. The proposed SPORE program is focused on 4 projects with the high potential translational impact, and there are 2 highly interactive cores that will continue to acquire, store, and make available a unique set of tissue samples, data (clinical, molecular genetic, biological, pathological), reagents and resources: Project 1: Immunotherapy of Pancreatic Adenocarcinoma Project 2: Inhibitors of N-cadherin in the treatment of pancreatic cancer. Project 3: Biological marker(s) in the diagnosis of pancreatic cancer Project 4: Inhibitors of Telomerase in treatment of pancreatic adenocarcinoma Core 1: Administration Core 2: Pancreas Tumor SPORE Tissue Bank Core 3: Biostatistics